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Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction |
112 |
104907 |
Jae HyunKim, Kilsoo Jung, Chulho Lee, Doona Song, Kibum Kim, Hee ChanYoo, Seung Joon Park, Jong Soon Kang, Kyeong-Ryoon Lee, Sunghoon Kim, Jung Min Han, Gyoon hee Han |
Bioorganic Chemistry |
July 2021 |
|
Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion |
12(569) |
eaax0091 |
Sangwoo Ham, Seung Pil Yun, Hyojung Kim, Donghoon Kim, Bo Am Seo, Heejeong Kim, Jeong-Yong Shin, Mohamad Aasif Dar, Gum Hwa Lee, Yun Il Lee, Doyeun Kim, Sunghoon Kim, Hee-Seok Kweon, Joo-Ho Shin, Han Seok Ko, Yunjong Lee |
Science translational medicine. |
20201111 |
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Extracellular vesicles derived from macrophage display glycyl-tRNA synthetase 1 exhibits anti-cancer activity Journal of Extracellular Vesicles |
in press |
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Peter G. et al. |
Journal of Extracellular Vesicles |
20201107 |
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Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer |
3(1) |
630 |
Jayoung Ku, Ryul Kim, Dongchan Kim, Daeyoon Kim, Seulki Song, Keonyong Lee, Namseok Lee, MinA Kim, Sung-Soo Yoon, Nam Hoon Kwon, Sunghoon Kim, Yoosik Kim, Youngil Koh |
Communications biology. |
20201030 |
| Integration Core |
Cell-based analysis of pairwise interactions between the components of the multi-tRNA synthetase complex |
in press |
. |
Kong JW et al. |
The FASEB Journal |
20200601 |
| Integration Core |
Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy |
63(10) |
5139-5158 |
Aneesh Sivaraman, Dae Gyu Kim, Deepak Bhattarai, Minkyoung Kim, Hwa Young Lee, Semi Lim, Jiwon Kong, Ja-Il Goo, Seunghwan Shim, Seungbeom Lee, Young-Ger Suh, Yongseok Choi, Sunghoon Kim, Kyeong Lee |
Journal of medicinal chemistry |
20200528 |
| Integration Core |
An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody |
10(6) |
E820 |
Dae Gyu Kim, Thi Thu Ha Nguyen, Nam Hoon Kwon, Junsik Sung, Semi Lim, Eun-Joo Kang, Jihye Lee, Woo Young Seo, Arum Kim, Yoon Soo Chang, Hyunbo Shim, Sunghoon Kim |
Biomolecules. |
20200527 |
| Integration Core |
Endogenous TLR2 Ligand Embedded in the Catalytic Region of Human cysteinyl-tRNA Synthetase 1 |
8(1) |
e000277 |
Seongmin Cho, Sang Bum Kim, Youngjin Lee, Ee Chan Song, Uijoo Kim, Hyeong Yun Kim, Ji Hun Suh, Peter C Goughnour, YounHa Kim, Ina Yoon, Na Young Shin, Doyeun Kim, Il-Kyu Kim, Chang-Yuil Kang, Song Yee Jang, Myung Hee Kim, Sunghoon Kim |
Journal for immunotherapy of cancer. |
20200508 |
| Integration Core |
2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Interacting Multifunctional Protein 2 (AIMP2)-DX2 for Lung Cancer Treatment |
63(8) |
3908-3914 |
Seungbeom Lee, Dae Gyu Kim, Kyeojin Kim, Taewoo Kim, Semi Lim, Hyejin Kong, Sunghoon Kim, Young-Ger Suh |
Journal of medicinal chemistry. |
20200423 |
| Integration Core |
Plasma Lysyl-tRNA Synthetase 1 (KARS1) as a novel diagnostic and prognostic biomarker for colorectal cancer |
9(2) |
533 |
Ji Hun Suh, Min Chul Park, Peter Goughnour, Byung Soh Min, Sangbum Kim, WooYoung Lee, Young Beom Cho, Jae Hee Cheon, Kang Young Lee, Do-Hyun Nam, Sunghoon Kim |
MDPI |
20200116 |
| Integration Core |
Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1. |
367(6474) |
205-210 |
Ina Yoon, Miso Nam, Hoi Kyoung Kim, Hee-Sun Moon, Sungmin Kim, Jayun Jang, Ji Ae Song, Seung Jae Jeong, Sang Bum Kim, Seongmin Cho, YounHa Kim, Jihye Lee, Won Suk Yang, Hee Chan Yoo, Kibum Kim, Min-Sun Kim, Aerin Yang, Kyukwang Cho, Hee-Sung Park, Geum-Sook Hwang, Kwang Yeon Hwang, Jung Min Han, Jong Hyun Kim, Sunghoon Kim |
Science |
20200110 |
| Integration Core |
PHD1 controls muscle mTORC1 in a hydroxylation independent manner by stabilizing leucyl tRNA synthetase |
11(1) |
174 |
Gommaar D'Hulst, Ines Soro-Arnaiz, Evi Masschelein, Koen Veys, Gillian Fitzgerald, Benoit Smeuninx, Sunghoon Kim, Louise Deldicque, Bert Blaauw, Peter Carmeliet, Leigh Breen, Peppi Koivunen, Shi-Min Zhao, and Katrien De Bock |
Nature Communications |
20191216 |
| Integration Core |
Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development. |
16 |
31-41 |
Semi Lim, Hye Young Cho, Dae Gyu Kim, Younah Roh, Se-Young Son, Ameeq Ul Mushtaq, Minkyoung Kim, Deepak Bhattarai, Aneesh Sivaraman, Youngjin Lee, Jihye Lee, Won Suk Yang, Hoi Kyoung Kim, Myung Hee Kim, Kyeong Lee, Young Ho Jeon & Sunghoon Kim |
Nature chemical biology |
20191202 |
| Integration Core |
Symmetric Assembly of a Decameric Subcomplex in Human Multi-tRNA Synthetase Complex Via Interactions between Glutathione Transferase-Homology Domains and Aspartyl-tRNA Synthetase. |
431(22) |
4475-4496 |
Ha Yeon Cho, Hyun Joo Lee, Yoon Seo Choi, Dong Kyu Kim, Kyeong Sik Jin, Sunghoon Kim, Beom Sik Kang |
Journal of molecular biology. |
20191108 |
| Practical Business |
Methionyl-tRNA Synthetase is a Useful Diagnostic Marker for Lymph Node Metastasis in Non-Small Cell Lung Cancer |
60(11) |
1005-1012 |
Jung Mo Lee, Taehee Kim, Eun Young Kim, Arum Kim, Dong Ki Lee, Nam Hoon Kwon, Sunghoon Kim, Yoon Soo Chang |
Yonsei Medical Journal |
20191101 |
| Integration Core |
ERK-dependent phosphorylation of the linker and substrate-binding domain of HSP70 increases folding activity and cell proliferation |
51(9) |
1-14 |
Semi Lim, Dae Gyu Kim, Sunghoon Kim |
Experimental and molecular medicine |
20190926 |
| Integration Core |
The DRS-AIMP2-EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex. |
6(Pt5) |
958-967 |
Hyunggu Hahn, Sang Ho Park, Hyun-Jung Kim, Sunghoon Kim, and Byung Woo Han |
IUCrJ |
20190901 |
| Practical Business |
Matrix Metalloproteinases Inactivate the Proinflammatory Functions of Secreted Moonlighting tryptophanyl-tRNA Synthetase. |
294(35) |
12866-12879 |
Parker G Jobin, Nestor Solis, Yoan Machado, Peter A Bell, Nam Hoon Kwon, Sunghoon Kim, Christopher M Overall, Georgina S Butler |
The Journal of biological chemistry. |
20190830 |
| Integration Core |
Aminoacyl-tRNA synthetases as therapeutic targets |
18(8) |
629-650 |
Nam Hoon Kwon, Paul Fox, Sunghoon Kim |
Nature Reviews Drug Discovery |
20190510 |
| Integration Core |
Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration |
130 |
2088-2093 |
Kook Son, Jae-Sung You, Mee-Sup Yoon, Chong Dai, Jong Hyun Kim, Nidhi Khanna, Aditi Banerjee, Susan A. Martinis, Gyoonhee Han, Jung Min Han, Sunghoon Kim, and Jie Chen |
Journal of Clinical Investigation |
20190416 |
| Integration Core |
Evolution of the multi-tRNA synthetase complex and its role in cancer |
294(14) |
5340-5351 |
Do Young Hyeon, Jong Hyun Kim, Tae Jin Ahn, Yeshin Cho, Daehee Hwang and Sunghoon Kim |
Journal of Biological Chemistry |
20190405 |
| Integration Core |
A threonyl-tRNA synthetase-mediated translation initiation machinery |
10(1) |
1357 |
Seung Jae Jeong, Shinhye Park, Loi T. Nguyen, Jungwon Hwang, Eun-Young Lee, Hoi-Khoanh Giong, Jeong-Soo Lee, Ina Yoon, Ji-Hyun Lee, Jong Hyun Kim, Hoi Kyoung Kim, Doyeun Kim, Won Suk Yang, Seon-Young Kim, Chan Yong Lee, Kweon Yu, Nahum Sonenberg, Myung Hee Kim, Sunghoon Kim |
Nature Communications |
20190322 |
| Practical Business |
Implementation of Web-based High-Throughput Screening Calculation System |
46(3) |
260-267 |
Seong-ho Cho, Inhee Kim, Jiwon Kong, Daesan Kim, Namhoon Kwon, Robert E. Burrier, Sunghoon Kim |
Journal of KIISE |
20190315 |
| Integration Core |
HIF1α‐mediated AIMP3 suppression delays stem cell aging via the induction of autophagy |
18(2) |
e12909 |
Chul Kim, Ji‐Min Park, Youngsook Song, Sunghoon Kim, Jisook Moon |
Aging Cell |
20190131 |
| Integration Core |
Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1) |
S0968-0896(18) |
32164-3 |
Suyoung Yoon, Sung-Eun Kim, Jong Hyun Kim, Ina Yoon, Phuong-Thao Tran, Jihye Ahn, Changhoon Kim, Woong Sub Byun, Sangkook Lee, Sunghoon Kim, Jiyoun Lee, Jeewoo Lee |
Bioorganic & Medicinal Chemistry |
20190130 |
| Integration Core |
Glycoprotein 96 Polymorphisms are Associated with the Risk of Systemic Lupus Erythematosus: A Case-Control Study |
22(5) |
905-912 |
Jeong Seok Lee, Churl Hyun Im, Sang Jin Lee, Ji Yong Choi, Jung Min Han, Sunghoon Kim, Dong Jo Kim, Taesung Park, Eun Young Lee, Yeong Wook Song |
International Journal of Rheumatic Diseases |
20190127 |
| Integration Core |
Released tryptophanyl-tRNA synthetase stimulates innate immune responses against viral infection |
93(2) |
e01291-18 |
Hyun-Cheol Lee, Eun-Seo Lee, Md Bashir Uddin, Tae-Hwan Kim, Jae-Hoon Kim, Kiramage Chathuranga, W. A. Gayan Chathuranga, Mirim Jin, Sunghoon Kim, Chul-Joong Kim, Jong-Soo Lee |
Journal of Virology |
20190104 |
| Integration Core |
Glutamyl-prolyl-tRNA synthetase induces fibrotic extracellular matrix via both transcriptional and translational mechanisms |
33(3) |
4341-4354 |
Dae-Geun Song, Doyeun Kim, Jae Woo Jung, Seo Hee Nam, Ji Eon Kim, Hye-Jin Kim, Jong Hyun Kim, Seo-Jin Lee, Cheol-Ho Pan, Sunghoon Kim, and Jung Weon Lee |
The FASEB JOURNAL |
20181228 |
| Integration Core |
Biocon’s target factory |
36(9) |
791-797 |
Thomas X Neenan, Robert E Burrier & Sunghoon Kim |
NATURE BIOTECHNOLOGY |
20180906 |
| Integration Core |
Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity |
18 |
31555-1 |
Park JS, Park MC, Lee KY, Goughnour PC, Jeong SJ, Kim HS, Kim HJ, Lee BJ, Kim S, Han BW |
Int J Biol Macromol |
20180829 |
| Integration Core |
Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors |
26(14) |
4073-4079 |
Yoon S, Zuo D, Kim JH, Yoon I, Ann J, Kim SE, Cho D, Kim WK, Lee S, Lee J, Kim S, Lee J. |
Bioorg Med Chem |
20180807 |
| Integration Core |
Liposomal Borrelidin for Treatment of Metastatic Breast Cancer |
8(5) |
1380-1388 |
Moonkyoung Jeong, Heegon Kim, Sunghoon Kim, Ji-Ho Park |
Drug Delivery and Translational Research |
20180710 |
| Integration Core |
Aminoacyl-tRNA synthetases, therapeutic targets for infectious diseases |
154(2018) |
424-434 |
Eun-Young Lee, Sunghoon Kim, Myung Hee Kim |
Biochemical Pharmacology |
20180608 |
| Integration Core |
Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway |
115(23) |
E5279-E5288 |
Minji Lee, Jong Hyun Kim, Ina Yoon, Chulho Lee, Mohammad Fallahi Sichani, Jong Soon Kang, Jeonghyun Kang, Min Guo, Kang Young Lee, Gyoonhee Han, Sunghoon Kim and Jung Min Han |
Preoceedings of the National Academy of Sciences of the United States of America(PNAS) |
20180605 |
| Integration Core |
Exosomal secretion of truncated cytosolic lysyl-tRNA synthetase induces inflammation during cell starvation |
2(5) |
119-121 |
Sang Bum Kim, Seongmin Cho, Sunghoon Kim |
Cell Stress |
20180508 |
| Practical Business |
Stabilization of cyclin dependent kinase 4 by methionyl-tRNA synthetase in p16INK4a-negative cancer |
in press |
|
Kwon, Nam Hoon; Lee , Jin Young; Ryu, Ye-lim ; Kim, Chanhee ; Kong, Jiwon ; Oh , Seongeun ; Kang, Beom Sik; Ahn , Hye Won ; Ahn , Sung Gwe; Jeong , Joon ; Kim , Hoi Kyoung ; Kim , Jong Hyun ; Han , Dae Young ; PARK, MIN CHUL; Kim , Doyeun ; Takase , Ryuichi ; Masuda , Isao ; Hou, Ya-Ming ; Jang , Sung Ill ; Chang , Yoon Soo ; Lee , Dong Ki ; Kim, Youngeun ; Wang , Ming-Wei ; Basappa, Kim, Sunghoon |
ACS Pharmacology & Translational Science |
20180421 |
| Integration Core |
AIMP1 Potentiates TH1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity |
8 |
1801 |
Dan Liang, Lin Tian, Ran You, Matthew M. Halpert, Vanaja Konduri, Yunyu C. Baig, Silke Paust, Doyeun Kim, Sunghoon Kim, Fuli Jia, Shixia Huang, Xiang Zhang, Farrah Kheradmand, David B. Corry, Brian E. Gilbert, Jonathan M. Levitt and William K. Decker |
Frontiers in Immunology |
20180115 |
| Integration Core |
Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration |
50(1) |
e424 |
Seung Jae Jeong, Jong Hyun Kim, Beom Jin Lim, Ina Yoon, Ji-Ae Song, Hee-sun Moon, Doyeun Kim, Dong Ki Lee and Sunghoon Kim |
Experimental & Molecular Medicine |
20180112 |
| Integration Core |
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction |
8(1) |
732 |
Jong Hyun Kim, Chulho Lee, Minji Lee, Haipeng Wang, Kibum Kim, Seung Joon Park, Ina Yoon, Jayun Jang, Hanchao Zhao, Hoi Kyoung Kim, Nam Hoon Kwon, Seung Jae Jeong, Hee Chan Yoo, Jae Hyun Kim, Jee Sun Yang, Myeong Youl Lee, Chang Woo Lee, Jieun Yun, Soo Jin Oh, Jong Soon Kang, Susan A. Martinis, Kwang Yeon Hwang, Min Guo, Gyoonhee Han, Jung Min Han & Sunghoon Kim- Show fewer authors |
Nature Communications |
20170929 |
| Integration Core |
Separation of extracellular nanovesicles and apoptotic bodies from cancer cell culture broth using tunable microfluidic systems. |
7(1) |
9907 |
Soojeong Shin, Daeyoung Han, Min Chul Park, Ji Young Mun, Jonghoon Choi, Honggu Chun, Sunghoon Kim & Jong Wook Hong |
Scientific Reports |
20170830 |
| Practical Business |
Transfer-RNA-mediated enhancement of ribosomal proteins S6 kinases signalling for cell proliferation. |
15(4-5) |
635-648 |
Nam Hoon Kwon, Mi Ran Lee, Jiwon Kong, Seung Kyun Park, Byung Joon Hwang, Byung Gyu Kim, Eun-Shin Lee, Hyeong-Gon Moon & Sunghoon Kim |
RNA biology |
20170817 |
| Integration Core |
Mapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry. |
12(8) |
e0181869 |
Yeqing Tao, Pengfei Fang, Sunghoon Kim, Min Guo, Nicolas L. Young, Alan G. Marshall |
PLoS One |
20170810 |
| Integration Core |
Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells. |
216(7) |
2201-2216 |
Sang Bum Kim, Hye Rim Kim, Min Chul Park, Seongmin Cho, Peter C. Goughnour, Daeyoung Han, Ina Yoon, YounHa Kim, Taehee Kang, Eunjoo Song, Pilhan Kim, Hyosun Choi, Ji Young Mun, Chihong Song, Sangmin Lee, Hyun Suk Jung, Sunghoon Kim |
The Journal of Cell Biology |
20170613 |
| Integration Core |
Serine 207 phosphorylated Lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma. |
8(39) |
65186-65198 |
Suliman Boulos, Min Chul Park, Marian Zeibak, Shen Yun Foo, Yoon Kyung Jeon, Young Tae Kim, Alex Motzik, Sagi Tshori, Tamar Hamburger, Sunghoon Kim, Hovav Nechushtan, Ehud Razin |
Oncotarget |
20170522 |
| Integration Core |
Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer. |
8(8) |
1347-1354 |
Ji Ye Jung, Eun Young Kim, Arum Kim, Joon Chang, Nam Hoon Kwon, Youngji Moon, Eun Joo Kang, Jun Sik Sung, Hyunbo Shim, Sunghoon Kim3, Yoon Soo Chang |
Journal of Cancer |
20170512 |
| Integration Core |
Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors. |
59(22) |
10322-10328 |
Suyoung Yoon, Jong Hyun Kim, Sung-Eun Kim, Changhoon Kim, Phuong-Thao Tran, Jihyae Ann, Yura Koh, Jayun Jang, Sungmin Kim, Hee-sun Moon, Won Kyung Kim, Sangkook Lee, Jiyoun Lee, Sunghoon Kim, Jeewoo Lee |
Journal of Medicinal Chemistry |
20161123 |
| Drug Screening |
A chemical biology route to site-specific authentic protein modifications. |
354(6312) |
623-626 |
Aerin Yang, Sura Ha, Jihye Ahn, Rira Kim, Sungyoon Kim, Younghoon Lee, Jaehoon Kim, Dieter Söll, Hee-Yoon Lee, Hee-Sung Park |
Science |
20161104 |
| Integration Core |
Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity |
17(11) |
1252-1262 |
Lee EY, Lee HC, Kim HK, Jang SY, Park SJ, Kim YH, Kim JH, Hwang J, Kim JH, Kim TH, Arif A, Kim SY, Choi YK, Lee C, Lee CH, Jung JU, Fox PL, Kim S, Lee JS, Kim MH |
Nature Immunology |
20161101 |
| Integration Core |
Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection. |
2 |
16191 |
Ahn YH, Park S, Choi JJ, Park BK, Rhee KH, Kang E, Ahn S, Lee CH, Lee JS, Inn KS, Cho ML, Park SH, Park K, Park HJ, Lee JH, Park JW, Kwon NH, Shim H, Han BW, Kim P, Lee JY, Jeon Y, Huh JW, Jin M, Kim S |
Nature Microbiology |
20161017 |
| Integration Core |
O-GlcNAcylation of orphan nuclear receptor ERRγ promotes hepatic gluconeogenesis. |
65(10) |
2835-2848 |
Jagannath Misra, Don-Kyu Kim, Yoon Seok Jung, Han Byeol Kim, Yong-Hoon Kim, Eun-Kyung Yoo, Byung Gyu Kim, Sunghoon Kim, In-Kyu Lee, Robert A. Harris, Jeong-Sun Kim, Chul-Ho Lee, Jin Won Cho, Hueng-Sik Choi |
Diabetes |
20161001 |
| Integration Core |
Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling. |
16(9) |
1510–1517 |
Mee-Sup Yoon, Kook Son, Edwin Arauz, Jung Min Han, Sunghoon Kim, Jie Chen |
Cell Reports |
20160809 |
| Integration Core |
AIMP2 controls intestinal stem cell compartments and tumorigenesis by modulating Wnt/β-catenin signaling. |
76(15) |
4559-4568 |
Min Kyu Yum, Jong-Seol Kang, Al-Eum Lee, Young-Woo Jo, Ji Yun Seo, Hyun-A Kim, Yoon-Young Kim, Jinwoo Seong, Eun Byul Lee, Ji-Hoon Kim, Jung Min Han, Sunghoon Kim, Young-Yun Kong |
Cancer Research |
20160801 |
| Integration Core |
Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor Suppressive Interaction with Smurf2. |
76(11) |
3422-3436 |
Dae Gyu Kim, Jin Young Lee, Ji-Hyun Lee, Ha Yeon Cho, Beom Sik Kang, Song-Yee Jang, Myung Hee Kim, Min Guo, Jung Min Han, Seong-Jin Kim, Sunghoon Kim |
Cancer Research |
20160701 |
| Integration Core |
Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase(LRS)-targeted mTORC1 inhibitor. |
26(13) |
3038-3041 |
Suyoung Yoon, Jong Hyun Kim, Ina Yoon, Changhoon Kim, Sung-Eun Kim, Yura Koh, Seung Jae Jeong, Jiyoun Lee, Sunghoon Kim, Jeewoo Lee |
Bioorganic & Medicinal Chemistry Letters |
20160701 |
| Integration Core |
Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell‑extracellular matrix adhesion for migration. |
48(4) |
1553-1560 |
Seo Hee Nam, Minkyung Kang, Jihye Ryu, Hye-Jin Kim, Doyeun Kim,Dae Gyu Kim, Nam Hoon Kwon, Sunghoon Kim, Jung Weon Lee |
International Journal of Oncology |
20160401 |
| Integration Core |
Novel morphological and genetic analysis of cancer cells in a 3D microenvironment identifies STAT3 as a regulator of tumor permeability barrier function. |
76(5) |
1044-1054 |
Min Chul park, Hyobin Jeong, Sung Hwa Son, Younha Kim, Daeyoung Han, Peter C. Goughnour, Taehee Kang, Nam Hoon Kwon, Hyo Eun Moon, Sun Ha Paek, Daehee Hwang, Ho Jun Seol, Do-Hyun Nam, Sunghoon Kim |
Cancer Research |
20160301 |
| Integration Core |
PharmDB-K: integrated bio-pharmacological network database for 1 Traditional Korean Medicine. |
10(11) |
e0142624 |
Ji-Hyun Lee, Kyoung Mii Park, Dong-Jin Han, Nam Young Bang, Do-Hee Kim, Hyeongjin Na, Semi Lim, Tae Bum Kim, Dae Gyu Kim, Hyun-Jung Kim, Yeonseok Chung, Sang Hyun Sung, Young-Joon Surh, Sunghoon Kim, Byung Woo Han |
Plos One |
20151110 |
| Integration Core |
Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-Homology Domains |
290(49) |
29313-29328 |
Ha Yeon Cho, Seo Jin Maeng, Hyo Je Cho, Yoon Seo Choi, Jeong Min Chung, Sangmin Lee, Hoi Kyoung Kim, Jong Hyun Kim, Chi-Yong Eom, Yeon-Gil Kim, Min Guo, Hyun Suk Jung, Beom Sik Kang, Sunghoon Kim |
Journal of Biological Chemistry |
20151015 |
| Integration Core |
Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer. |
112(40) |
12492-12497 |
Hansoo Park, Sung-Yup Cho, Hyerim Kim, Deukchae Na, Jee Yun Han, Jeesoo Chae, Changho Park, Ok-Kyoung Park, Seoyeon Min, Jinjoo Kang, Boram Choi, Jimin Min, Jee Young Kwon, Yun-Suhk Suh, Seong-Ho Kong, Hyuk-Joon Lee, Edison T. Liu, Jong-Il Kim, Sunghoon Kim, Han-Kwang Yang, Charles Lee |
Proceedings of the National Academy of Sciences of the United States of America |
20151006 |
| Integration Core |
Screening of quinoline, 1,2-benzoxazine, and 1,3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis. |
13(26) |
9381-9387 |
Hanumantharayappa Bharathkumar, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Taehee Kang, H.K. Keerthy, Julian E. Fuchs, Nam Hoon Kwon, Andreas Bender, Sunghoon Kim, Basappa, Kanchugarakoppal S. Rangappa |
Organic and Biomolecular Chemistry |
20150928 |
| Integration Core |
Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels. |
6(25) |
21655-21674 |
Nam SH, Kim D, Lee MS, Lee D, Kwak TK, Kang M, Ryu J, Kim HJ, Song HE, Choi J, Lee GH, Kim SY, Park SH, Kim DG, Kwon NH, Kim TY, Thiery JP, Kim S, Lee JW |
Oncotarget |
20150828 |
| Integration Core |
A novel in vitro permeability assay using three-dimensional cell culture system. |
205 |
93-100 |
Jong Bong Lee, Sung Hwa Son, Min Chul Park, Tae Hwan Kim, Min Gi Kim, Sun Dong Yoo, Sunghoon Kim |
Journal of Biotechnology |
20150710 |
| Integration Core |
The BioMart Community Portal: an innovative alternative to large, centralized data repositories. |
43(W1) |
W589-598 |
Byung Woo Han, Ji-Hyun Lee, Sunghoon Kim 외 99인 |
Nucleic Acids Research |
20150701 |
| Integration Core |
Tpl2 induces castration resistant prostate cancer progression and metastasis. |
136(9) |
2065-2077 |
Hye Won Lee, Hyun Jung Cho, Se Jeong Lee, Hye Jin Song, Hee Jin Cho, Min Chul Park, Ho Jun Seol, Jung-Il Lee, Sunghoon Kim, Hyun Moo Lee, Han Yong Choi, Do-Hyun Nam, Kyeung Min Joo |
International Journal of Cancer |
20150501 |
| Integration Core |
1H, 13C and 15N resonance assignment of WHEP domains of human glutamyl-prolyl tRNA synthetase. |
9(1) |
25-30 |
ChinHo Shin, Geum-Sook Hwang, Hee-Chul Ahn, Sunghoon Kim, Key-Sun Kim |
Biomolecular NMR Assignments |
20150401 |
| Drug Design |
Liposome-Based Engineering of Cells To Package Hydrophobic Compounds in Membrane Vesicles for Tumor Penetration. |
15(5) |
2938-2944 |
Junsung Lee, Jiyoung Kim, Moonkyoung Jeong, Hyoungjin Lee, Unbyeol Goh, Hyaeyeong Kim, Byungji Kim, Ji-Ho Park |
Nano Letters |
20150331 |
| Integration Core |
Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. |
6 |
6402 |
Pengfei Fang, Xue Yu, Seung Jae Jeong, Adam Mirando, Kaige Chen, Xin Chen, Sunghoon Kim, Christopher S. Francklyn, Min Guo |
Nature Communications |
20150331 |
| Integration Core |
Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer. |
2015 |
1-14 |
Ji-Hyun Lee, Sungyong You, Do Young Hyeon, Byeongsoo Kang, Hyerim Kim, Kyoung Mii Park, Byungwoo Han, Daehee Hwang, Sunghoon Kim |
Database |
20150329 |
| Integration Core |
miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18. |
36(6) |
9724 |
Seunghee Lee, Kyung-Rok Yu, Young-Sil Ryu, Young Sun Oh, In-Sun Hong, Hyung-Sik Kim, Jin Young Lee, Sunghoon Kim, Kwang-Won Seo, Kyung-Sun Kang |
American Aging Association |
20141204 |
| Integration Core |
A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells. |
6(6) |
1402-1414 |
Dong-Ki Choi1, Jeomil Bae1, Seung-Min Shin, Ju-Yeon Shin, Sunghoon Kim, Yong-Sung Kim |
MAbs |
20141102 |
| Integration Core |
Structure of the ArgRS–GlnRS–AIMP1 complex and its implications for mammalian translation. |
111(42) |
15084-15089 |
Yaoyao Fu, Youngran Kim, Kyeong Sik Jin, Hyun Sook Kim, Jong Hyun Kim, DongMing Wang, Minyoung Park, Chang Hwa Jo, Nam Hoon Kwon, Doyeun Kim, Myung Hee Kim, Young Ho Jeon, Kwang Yeon Hwang, Sunghoon Kim, Yunje Cho |
Proceedings of the National Academy of Sciences of the United States of America |
20141021 |
| Integration Core |
AIMP1/p43 negatively regulates adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma. |
127(20) |
4483-4493 |
Jong Hyun Kim, Jung Ho Lee, Min Chul Park, Ina Yoon, Kibom Kim, Minji Lee, Heung-Sik Choi, Sunghoon Kim, Jung Min Han |
Journal of Cell Science |
20141015 |
| Integration Core |
Promiscuous methionyl-tRNA synthetase mediates adaptive mistranslation against oxidative stresses. |
127(19) |
4234-4245 |
Jin Young Lee, Dae Gyu Kim, Byung-Gyu Kim, Won Suk Yang, Jeena Hong, Taehee Kang, Young Sun Oh, Kyung Rok Kim, Byung Woo Han, ByungJoon Hwang, BeomSik Kang, Mi-Sun Kang, Myung-Hee Kim, Nam Hoon Kwon, Sunghoon Kim |
Journal of Cell Science |
20141001 |
| Integration Core |
Characterization of the interaction between lysyl-tRNA synthetase and laminin receptor by NMR. |
588(17) |
2851-2858 |
Hye Young Cho, Ameeq Ul Mushtaq, Jin Young Lee, Dae Gyu Kim, Min Sook Seok, Minseok Jang, Byung-Woo Han, Sunghoon Kim, Young Ho Jeon |
Febs letters |
20140825 |
| Integration Core |
Translational validation of personalized treatment strategy based on genetic characteristics of glioblastoma. |
9(8) |
e103327 |
Young Taek Oh, Hee Jin Cho, Jinkuk Kim, Ji-Hyun Lee, Kyoohyoung Rho, Yun-Jee Seo, Yeon-Sook Choi, Hye Jin Jung, Hyeon Suk Song, Doo-Sik Kong, Ho Jun Seol, Jung-Il Lee, Yeup Yoon, Sunghoon Kim, Do-Hyun Nam1, Kyeung Min Joo |
Plos One |
20140801 |
| Target ID |
The crystal structure of arginyl-tRNA synthetase from Homo sapiens. |
588(14) |
2328-2334 |
Hyun Sook Kim, So Young Cha, Chang Hwa Jo, Ahreum Han, Kwang Yeon Hwang |
FEBS Letters |
20140727 |
| Integration Core |
Degradation of AIMP1/p43 induced by hepatitis C virus E2 leads to upregulation of TGF-β signaling and increase in surface expression of gp96. |
9(5) |
e96302 |
Min Soo Kim, Sunghoon Kim, Heejoon Myung |
Plos One |
20140509 |
| Integration Core |
A novel adenoviral vector-mediated mouse model of Charcot-Marie-Tooth type 2D (CMT2D). |
45(2) |
121-128 |
Ah Jung Seo, Youn Ho Shin, Seo Jin Lee, Doyeun Kim, Byung Sun Park, Sunghoon Kim, Kyu Ha Choi, Na Young Jeong, Chan Park, Ji-Yeon Jang, Youngbuhm Huh, Junyang Jung |
Journal of Molecular Histology |
20140401 |
| Integration Core |
A novel adenoviral vector-mediated mouse model of Charcot-Marie-Tooth type 2D (CMT2D). |
45(2) |
121-128 |
Ah Jung Seo, Youn Ho Shin, Seo Jin Lee, Doyeun Kim, Byung Sun Park, Sunghoon Kim, Kyu Ha Choi, Na Young Jeong, Chan Park, Ji-Yeon Jang, Youngbuhm Huh, Junyang Jung |
Mol Histol |
20140401 |
| Target ID |
The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein. |
5 |
2958 |
Jungwon Hwang, Hyun-Woo Suh, Young Ho Jeon, Eunha Hwang, Loi T. Nguyen, Jeonghun Yeom, Seung-Goo Lee, Cheolju Lee, Kyung Jin Kim, Beom Sik Kang, Jin-Ok Jeong, Tae-Kwang Oh, Inpyo Choi, Jie-Oh Lee, Myung Hee Kim |
Nature Communications |
20140106 |
| Integration Core |
Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction. |
10(1) |
29-34 |
Dae Gyu Kim, Jin Young Lee, Nam Hoon Kwon, Pengfei Fang, Qian Zhang, Jing Wang, Nicolas L Young, Min Guo, Hye Young Cho, Ameeq Ul Mushtaq, Young Ho Jeon, Jin Woo Choi, Jung Min Han, Ho Woong Kang, Jae Eun Joo, Youn Hur, Wonyoung Kang, Heekyoung Yang, Do-Hyun Nam, Mi-Sook Lee, Jung Weon Lee, Eun-Sook Kim, Aree Moon, Kibom Kim, Doyeun Kim, Eun Joo Kang, Youngji Moon, Kyung Hee Rhee, Byung Woo Han, Jee Sun Yang, Gyoonhee Han, Won Suk Yang, Cheolju Lee, Ming-Wei Wang, Sunghoon Kim |
Nature Chemical Biology |
20140101 |
| Drug Design |
The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. |
4 |
3000 |
Dong Ju Son, Sandeep Kumar, Wakako Takabe, Chan Woo Kim, Chih-Wen Ni, Noah Alberts-Grill, In-Hwan Jang, Sangok Kim, Wankyu Kim, Sang Won Kang, Andrew H. Baker, Jai Woong Seo, Katherine W. Ferrara, Hanjoong Jo |
Nature Communications |
20131218 |
| Integration Core |
Tpl2 kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma. |
11(11) |
1375-1386 |
Hye Won Lee, Kyeung Min Joo, Joung Eun Lim, Hyun Jung Cho, Hee Jin Cho, Min Chul Park, Ho Jun Seol, Seong Il Seo, Jung-Il Lee, Sunghoon Kim, Byong Chang Jeong, Do-Hyun Nam |
Molecular Cancer Research |
20131101 |
| Integration Core |
Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex. |
81(10) |
1840-1846 |
Kyung Rok Kim, Sang Ho Park, Hyoun Sook Kim, Kyung Hee Rhee, Byung-Gyu Kim, Dae Gyu Kim, Mi Seul Park, Hyun-Jung Kim, Sunghoon Kim, Byung Woo Han |
Proteins |
20131001 |
| Target ID |
Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex. |
81(10) |
1840-1846 |
Kyung Rok Kim, Sang Ho Park, Hyoun Sook Kim, Kyung Hee Rhee, Byung-Gyu Kim, Dae Gyu Kim, Mi Seul Park, Hyun-Jung Kim, Sunghoon Kim, Byung Woo Han |
Proteins |
20131001 |
| Integration Core |
Protein-protein interactions and multi-component complexes of aminoacyl-tRNA synthetases. |
2014(344) |
119-44 |
Jong Hyun Kim, Jung Min Han, Sunghoon Kim |
Topics in Current Chemistry |
20130927 |
| Integration Core |
Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumor regression. |
454(3) |
411-416 |
Hee Sook Lee, Dae Gyu Kim, Young Sun Oh, Nam Hoon Kwon, Jin Young Lee, Doyeun Kim, Song-Hwa Park, Jong-Hwan Song, Sunkyung lee, Jung Min Han, Bum-Joon Park, Jongkook Lee, Sunghoon Kim |
Biochemical Journal |
20130915 |
| Integration Core |
Identification of upstream regulators for prognostic expression signature genes in colorectal cancer. |
7 |
86 |
Taejeong Bae, Kyoohyoung Rho, Jin Woo Choi, Katsuhisa Horimoto, Wankyu Kim, Sunghoon Kim |
BMC Systems Biology |
20130904 |
| Integration Core |
Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone. |
D69 |
2136-2145 |
Jonghyeon Son, Eun Hye Lee, Minyoung Park, Jong Hyun Kim, Junsoo Kim, Sunghoon Kim, Young Ho Jeon, Kwang Yeon Hwang |
Acta Crystallographica Section D |
20130724 |
| Target ID |
Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR. |
110(30) |
E2829-37 |
Jungwon Hwang, Byoung Sik Kim, Song Yee Jang, Jong Gyu Lim, Dong-Ju You, Hyun Suk Jung, Tae-Kwang Oh, Jie-Oh Lee, Sang Ho Choi, Myung Hee Kim |
Proceedings of the National Academy of Sciences of the United States of America |
20130723 |
| Integration Core |
Association of aminoacyl-tRNA synthetases with cancer. |
2014(344) |
207-45 |
Doyeun Kim, Nam Hoon Kwon, Sunghoon Kim |
Topics in Current Chemistry |
20130702 |
| Integration Core |
Multiple reaction monitoring of multiple low-abundance transcription factors in whole lung cancer cell lysates |
12(6) |
2582-2596 |
Jun Seok Kim, Youngju Lee, Min Young Lee, Jihye Shin, Jung Min Han, Eun Gyeong Yang, Myeong-Hee Yu, Sunghoon Kim, Daehee Hwang, Cheolju Lee |
Journal of Proteome Research |
20130415 |
| Integration Core |
Patient-specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ. |
3(1) |
260-273 |
Kyeung Min Joo, Jinkuk Kim, Juyoun Jin, Misuk Kim, Ho Jun Seol, Johongir Muradov, Heekyoung Yang, Yoon-La Choi, Woong-Yang Park, Doo-Sik Kong, Jung-Il Lee, Young-Hyeh Ko,3,5 Hyun Goo Woo, Jeongwu Lee, Sunghoon Kim, Do-Hyun Nam |
Cell Reports |
20130131 |
| Integration Core |
Structural switch of lysyl-tRNA synthetase between translation and transcription. |
49(1) |
30-42 |
Yifat Ofir-Birin, Pengfei Fang, Steven P. Bennett, Hui-Min Zhang, Jing Wang, Inbal Rachmin, Ryan Shapiro, Jing Song, Arie Dagan, Jorge Pozo, Sunghoon Kim, Alan G. Marshall, Paul Schimmel, Xiang-Lei Yang, Hovav Nechushtan, Ehud Razin, Min Guo |
Molecular Cell |
20130110 |
| Integration Core |
AIMP3/p18 controls translational initiation by mediating the delivery of charged initiator tRNA to initiation complex. |
423(4) |
475-481 |
Taehee Kang, Nam Hoon Kwon, Jin Young Lee, Min Chul Park, Eunji Kang, Hyo Hyun Kim, Taek Jin Kang, Sunghoon Kim |
Journal of Molecular Biology |
20121102 |
| Integration Core |
Cancer association study of aminoacyl-tRNA synthetase signaling network in glioblastoma. |
7(8) |
e40960 |
Yong-Wan Kim, ChangHyuk Kwon, Juinn-Lin Liu, Se Hoon Kim, Sunghoon Kim |
PLos One |
20120831 |
| Integration Core |
CDA: Combinatorial drug discovery using transcriptional response modules. |
7(8) |
1-10 |
Ji-Hyun Lee, Dae Gyu Kim, Tae Jeong Bae, Kyoohyoung Rho, Ji-Tae Kim, Jong-Jun Lee, Yeongjun Jang, Byung Cheol Kim, Kyoung Mii Park, Sunghoon Kim |
PLoS One |
20120808 |
| Target ID |
The diagnostic utility of the GNAS mutation in patients with fibrous dysplasia: meta-analysis of 168 sporadic cases. |
43(8) |
1234-1242 |
Seung Eun Lee, Eun Hee Lee, Heejung Park, Ji-Youn Sung, Hyoun Wook Lee, So Young Kang, Sungwook Seo, Byung Heon Kim, Hyojin Lee, An Na Seo, Geunghwan Ahn, Yoon-La Choi |
Human Pathology |
20120801 |
| Drug Screening |
Srs2 possesses a non-canonical PIP box in front of its SBM for precise recognition of SUMOylated PCNA. |
4(4) |
258-261 |
Seong Ok Kim, Hyerim Yoon, Seong Oak Park, Miju Lee, Jae-Sun Shin, Kyoung-Seok Ryu, Jie-Oh Lee, Yeon-soo Seo, Hyun Suk Jung, Byong-Seok Choi |
Journal of Molecular Cell Biology |
20120709 |
| Integration Core |
Identification of CD23 as a functional receptor for the proinflammatory cytokine AIMP1/p43. |
125 |
4620–4629 |
Hyuk-Sang Kwon, Min Chul Park, Dae Gyu Kim, Ki Won Jo, Young Woo Park, Jung Min Han, Sunghoon Kim |
Journal of Cell Science |
20120705 |
| Integration Core |
Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug. |
6(1) |
e80 |
Hee Sook Lee, Taejeong Bae, Ji-Hyun Lee, Dae Gyu Kim, Young Sun Oh, Yeongjun Jang, Ji-Tea Kim, Jong-Jun Lee, Alessio Innocenti, Claudiu T Supuran, Luonan Chen, Kyoohyoung Rho, Sunghoon Kim |
BMC Systems Biology |
20120702 |
| Integration Core |
Interaction of two translational components, lysyl-tRNA synthetase and p40/37LRP, in plasma membrane promotes laminin-dependent cell migration. |
26(10) |
4142-4159 |
Dae Gyu Kim, Jin Woo Choi, Jin Young Lee, Hyerim Kim, Young Sun Oh, Jung Weon Lee, Yu Kyung Tak, Joon Myong Song, Razin Ehud, Seok-Hyun Yun, Sunghoon Kim |
The FASEB Journal |
20120702 |
| Target ID |
Expression profiling of more than 3500 proteins of MSS-type colorectal cancer by stable isotope labeling and mass spectrometry. |
75(10) |
3050-3062 |
Un-Beam Kang, Jeonghun Yeom, Hye-Jung Kim, Hoguen Kim, Cheolju Lee |
Journal of Proteomics |
20120606 |
| Integration Core |
Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer. |
4(3) |
164-173 |
Jin Woo Choi, Jeong-Won Lee, Jun Ki Kim, Hye-Kyung Jeon, Jung-Joo Choi, Dae Gyu Kim, young-Gie Kim, Do-Hyun Nam, Hong Joong Kim, Seok Hyun Yun, Sunghoon Kim |
Journal of Molecular Cell Biology |
20120604 |
| Integration Core |
AIMP1 deficiency enhances airway hyperreactivity in mice via increased TH2 immune responses. |
143(3) |
256–265 |
Hye-Jin Hong, Eugene Kim, Mi Young Jung, Sunghoon Kim, Tae Sung Kim |
Clinical Immunology |
20120601 |
| Target ID |
Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing. |
51(6) |
590-597 |
Yeonjoo Jung, Pora Kim, Yeonhwa Jung, Juhee Keum, Soon-Nam Kim, Yong Soo Choi, In-Gu Do, Jinseon Lee, So-Jung Choi, Sujin Kim, Jong-Eun Lee, Jhingook Kim, Sanghyuk Lee, Jaesang Kim |
Genes Chromosomes Cancer |
20120601 |
| Target ID |
Mutated IDH1 is a favorable prognostic factor for type 2 gliomatosis cerebri. |
22(3) |
307-317 |
Mi Jung Kwon, Sung Tae Kim, Mi Jeong Kwon, Doo-Sik Kong, Dageun Lee, Sanghui Park, So Young Kang, Ji-Young Song, Do-Hyun Nam, Yukinari Kato, Yoon-La Choi, Yeon-Lim Suh |
Brain Pathology |
20120501 |
| Disease Modeling |
Oxidative stress-induced biomarkers for stem cell-based chemical screening. |
54 Suppl |
S42-49 |
Se-Ran Yanga, Irfan Rahmand, James E. Troskoe, Kyung-Sun Kang |
Preventive Medicine |
20120501 |
| Integration Core |
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. |
8(6) |
547-554 |
Mathew Sajish, Quansheng Zhou, Shuji Kishi, Delgado M Valdez Jr, Mili Kapoor, Min Guo, Sunhee Lee, Sunghoon Kim, Xiang-Lei Yang, Paul Schimmel |
Nature Chemical Biology |
20120415 |
| Integration Core |
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. |
149(2) |
410-424 |
Jung Min Han, Seung Jae Jeong, Min Chul Park, Gyuyoup Kim, Nam Hoon Kwon, Hoi Kyoung Kim, Sang Hoon Ha, Sung Ho Ryu, Sunghoon Kim |
Cell |
20120413 |
| Drug Screening |
Asymmetric mode of Ca²⁺-S100A4 interaction with nonmuscle myosin IIA generates nanomolar affinity required for filament remodeling. |
20(4) |
654-666 |
Paul R. Elliott, Andrew F. Irvine, Hyun Suk Jung, Kaeko Tozawa, Martyna W. Pastok, Remigio Picone, Sandip K. Badyal, Jaswir Basran, Philip S. Rudland, Roger Barraclough, Lu-Yun Lian, Clive R. Bagshaw, Marina Kriajevska, Igor L. Barsukov |
Structure |
20120404 |
| Target ID |
A prognostic model for lymph node-negative breast cancer patients based on the integration of proliferation and immunity. |
132(2) |
499-509 |
Ensel Oh, Yoon-La Choi, Taesung Park, Seungyeoun Lee, Seok Jin Nam, Young Kee Shin |
Breast Cancer Research and Treatment |
20120401 |
| Integration Core |
Chemical modulators working at pharmacological interface of target proteins. |
20(6) |
1893-1901 |
Young Ho Jeon, Jin Young Lee, Sunghoon Kim |
Bioorganic & Medicinal Chemistry |
20120315 |
| Target ID |
Chemical modulators working at pharmacological interface of target proteins. |
20(6) |
1893-1901 |
Young Ho Jeon, Jin Young Lee, Sunghoon Kim |
Bioorganic & Medicinal Chemistry |
20120315 |
| Integration Core |
Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. |
109(11) |
E640-647 |
Min Chul Park, Taehee Kang, Da Jin, Jung Min Han, Sang Bum Kim, Yoon Chung Park, Kiwon Cho, Young Woo Park, Weiwei He, Xiang-Lei Yang, Paul Schimmel, Sunghoon Kim |
Proceedings of the National Academy of Sciences of the United States of America |
20120313 |
| Target ID |
Crystal structure of the NurA-dAMP-Mn2+ complex. |
40(5) |
2258-2570 |
Jina Chae, Young Chang Kim, Yunje Cho |
Nucleic Acids Research |
20120301 |
| Target ID |
Clinical significance of CD151 overexpression in subtypes of invasive breast cancer. |
106(5) |
923-930 |
Kwon MJ, Park S, Choi JY, Oh E, Kim YJ, Park YH, Cho EY, Kwon MJ, Nam SJ, Im YH, Shin YK, Choi YL |
British Journal of Cancer |
20120228 |
| Disease Modeling |
Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition. |
1823(2) |
514-523 |
Mi-Sook Lee, Hwang-Phill Kim, Tae-You Kim, Jung Weon Lee |
Biochimica et Biophysica Acta |
20120201 |
| Disease Modeling |
Antagonistic regulation of transmembrane 4 L6 family member 5 attenuates fibrotic phenotypes in CCl(4) -treated mice. |
279(4) |
625-35 |
Minkyung Kang, Soo-Jin Jeong, Sook Young Park, Hyo Jeong Lee, Hyun Jeong Kim, Ki Hun Park, Sang-Kyu Ye, Sung-Hoon Kim, Jung Weon Lee |
FEBS Journal |
20120201 |
| Disease Modeling |
JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27(Kip1) phosphorylation. |
314(2) |
198-205 |
Hyeonjung Kim, Oisun Jung, Minkyung Kang, Mi-Sook Lee, Doyoung Jeong, Jihye Ryu, Youra Ko, Yoon-Ju Choi, Jung Weon Lee |
Cancer Letters |
20120128 |
| Target ID |
Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane. |
26(1) |
219-228 |
Jeong Soon Par, Woo Cheol Lee, Kwon Joo Yeo, Kyoung-Seok Ryu, Malika Kumarasiri, Dusan Hesek, Mijoon Lee, Shahriar Mobashery, Jung Hyun Song, Seung Il Kim, Je Chul Lee, Chaejoon Cheong, Young Ho Jeon, Hye-Yeon Kim |
FASEB Journal |
20120101 |
| Target ID |
Structural and functional characterization of Helicobacter pylori DsbG. |
585(24) |
3862-3867 |
Ji Young Yoon, Jieun Kim, Sang Jae Lee, Hyoun Sook Kim, Ha Na Im, Hye-Jin Yoon, Kyoung Hoon Kim, Soon-Jong Kim, Byung Woo Han, Se Won Suh |
FEBS Lett |
20111215 |
| Target ID |
Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents. |
21(24) |
7509-7512 |
Dao Thi Kim Oanh, Hoang Van Hai, Sang Ho Park, Hyun-Jung Kim, Byung-Woo Han, Hyung-Sook Kim, Jin-Tae Hong, Sang-Bae Han, Van Thi My Hue, Nguyen-Hai Nam |
Bioorganic & Medicinal Chemistry Letters |
20111215 |
| Integration Core |
Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3. |
108(49) |
19635-19640 |
Nam Hoon Kwon, Taehee Kang, Jin Young Lee, Hyo Hyun Kim, Hye Rim Kim, Jeena Hong, Young Sun Oh, Jung Min Han, Min Jeong Ku, Sang Yeol Lee, Sunghoon Kim |
Proceedings of the National Academy of Sciences of the United States of America |
20111206 |
| Target ID |
Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling. |
31(23) |
4775-4788 |
Nam-Shik Kim, Hyoung-Tai Kim, Min-Chul Kwon, Suk-Won Choi, Yoon-Young Kim, Ki-Jun Yoon, Bon-Kyoung Koo, Myung-Phil Kong, Juhee Shin, Yunje Cho, Young-Yun Kong |
Molecular and Cellular Biology |
20111201 |
| Disease Modeling |
Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling. |
31(23) |
4775-4788 |
Nam-Shik Kim, Hyoung-Tai Kim, Min-Chul Kwon, Suk-Won Choi, Yoon-Young Kim, Ki-Jun Yoon, Bon-Kyoung Koo, Myung-Phil Kong, Juhee Shin, Yunje Cho, Young-Yun Kong |
Molecular and Cellular Biology |
20111201 |
| Disease Modeling |
Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression. |
6(11) |
e28068 |
Ji-Won Jung, Sang-Bum Park, Soo-Jin Lee, Min-Soo Seo, James E. Trosko, Kyung-Sun Kang |
PLoS One |
20111123 |
| Target ID |
Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein. |
18(12) |
1336-1344 |
Hye-Ra Lee, Won-Chan Choi, Stacy Lee, Jungwon Hwang, Eunha Hwang, Koushik Guchhait, Juergen Haas, Zsolt Toth, Young Ho Jeon, Tae-Kwang Oh, Myung Hee Kim, Jae U Jung |
Nature Structural & Molecular Biology |
20111106 |
| Integration Core |
Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemokine activity towards human endothelial cells. |
5(11) |
e1398 |
Manuel Castro de Moura, Francesc Miro, Jung Min Han, Sunghoon Kim, Antonio Celada, Lluis Ribas de Pouplana |
PLoS Neglected Tropical Disease |
20111105 |
| Target ID |
Crystal structure of Arabidopsis thaliana 12-oxophytodienoate reductase isoform 3 in complex with 8-iso prostaglandin A(1). |
79(11) |
3236-41 |
Byung Woo Han, Thomas E. Malone, Do Jin Kim, Craig A. Bingman, Hyun-Jung Kim, Brian G. Fox, George N. Phillips Jr |
Proteins |
20111101 |
| Drug Screening |
Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells. |
36(11) |
2083-2090 |
Hyoseok Yi, Seong Jin Lee, Jiyeong Lee, Chang-Seon Myung, Woo-Kyu Park, Hee-Jong Lim, Ge Hyeong Lee, Jae Yang Kong, Heeyeong Cho |
Neurochem Res |
20111101 |
| Drug Design |
One target, different effects: a comparison of distinct therapeutic antibodies against the same targets. |
43(10) |
539-549 |
Hyunbo Shim |
Experimental and Molecular Medicine |
20111031 |
| Target ID |
Crystal structure of Mycobacterium tuberculosis Rv3168: a putative aminoglycoside antibiotics resistance enzyme. |
79(10) |
2983-2987 |
Sangwoo Kim, Chi My Thi Nguyen, Eun-Jung Kim, Kyung-Jin Kim |
Proteins |
20111001 |
| Target ID |
Overexpression, crystallization and preliminary X-ray crystallographic analysis of the C-terminal cytosolic domain of mouse anoctamin 1. |
67(Pt 10) |
1250-1252 |
Sang Ho Park, Ho Kyung Chung, Do Jin Kim, Mi Ra Han, Mi Seul Park, Uhtaek Oh, Hyun-Jung Kim, Byung Woo Han |
Acta Crystallogr Sect F Struct Biol Cryst Commun |
20111001 |
| Drug Screening |
Programming magnetic anisotropy in polymeric microactuators. |
10(10) |
747-52 |
Jiyun Kim, Su Eun Chung, Sung-Eun Choi, Howon Lee, Junhoi Kim, Sunghoon Kwon |
Nature Materials |
20111001 |
| Disease Modeling |
Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality. |
1813(10) |
1777-1783 |
Han Jeong Lim, Yoon Jeon, Chang Hwan Jeon, Jong Hyun Kim, Ho Lee |
Biochimica et Biophysica Acta |
20111001 |
| Integration Core |
Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping. |
11(10) |
708-718 |
Sunghoon Kim, Sungyong You, Daehee Hwang |
Nature Reviews Cancer |
20110928 |
| Integration Core |
Enhancement of toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells. |
134(1) |
73–81 |
Eugene Kim, Hye-Jin Hong, Daeho Cho, Jung Min Han, Sunghoon Kim, Tae Sung Kim |
Immunology |
20110901 |
| Drug Screening |
In situ fabrication and actuation of polymer magnetic microstructures. |
20(1) |
785-787 |
Su Eun Chung, Jiyun Kim, Sung-Eun Choi, Lily Nari Kim, Sunghoon Kwon |
JMEMS Letters |
20110801 |
| Target ID |
Crystal structure of the Mre11-Rad50-ATPγS complex: understanding the interplay between Mre11 and Rad50. |
25(10) |
1091-1104 |
Hye Seong Lim, Jin Seok Kim, Young Bong Park, Gwang Hyeon Gwon, Yunje Cho |
Genes & Development |
20110515 |
| Integration Core |
Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells. |
31(10) |
2111-2121 |
Irit Carmi-Levy, Alex Motzik, Yifat Ofir-Birin, Zohar Yagil, Christopher Maolin Yang, David Michael Kemeny, Jung Min Han, Sunghoon Kim, Gillian Kay, Hovav Nechushtan, Ryo Suzuki, Juan Rivera, Ehud Razin |
Molecular and Cellular Biology |
20110501 |
| Target ID |
Solution structure of the Zbeta domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B- and Z-DNAs. |
108(17) |
6921-6926 |
Kyungmin Kim, Bulat I. Khayrutdinov, Chung-Kyung Lee, Hae-Kap Cheong, Sung Wook Kang, Hyejin Park, Sangho Lee, Yang-Gyun Kim, JunGoo Jee, Alexander Rich, Kyeong Kyu Kim, Young Ho Jeon |
Proceedings of the National Academy of Sciences of the United States of America |
20110426 |
| Integration Core |
Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis. |
7(3) |
e1001351 |
Jin Woo Choi, Dae Gyu Kim, Al-Eum Lee, Hye Rim Kim, Jin Young Lee, Nam Hoon Kwon, Young Kee Shin, Soon-Kyung Hwang, Seung-Hee Chang, Myung-Haing Cho, Yoon-La Choi, Jhingook Kim, Seung Hyun Oh, Bora Kim, Soo-Youl Kim, Hyo-Sung Jeon, Jae Yong Park, Hyunseok Peter Kang, Bum Joon Park, Jung Min Han, Sunghoon Kim |
PLoS Genetics |
20110301 |
| Integration Core |
GARNET-gene set analysis with exploration of annotation relations. |
12(Suppl 1) |
S25 |
Kyoohyoung Rho, Bumjin Kim, Youngjun Jang, Sanghyun Lee, Taejeong Bae, Jihae Seo, Chaehwa Seo, Jihyun Lee, Hyunjung Kang, Ungsik Yu, Sunghoon Kim, Sanghyuk Lee, Wan Kyu Kim, Sanghyuk Lee |
BMC Bioinformatics |
20110215 |
| Drug Screening |
Polymer based chemical delivery to multichannel capillary patterned cells. |
11(4) |
605-608 |
Sung Hoon Lee, Austen James Heinz, Sung-Eun Choi, Wook Park, Sunghoon Kwon |
Lab on a Chip |
20110211 |
| Drug Screening |
Active guidance of 3D microstructures. |
6(23) |
2668-2672 |
Sung Hoon Lee, Sung-Eun Choi, Austen James Heinz, Wook Park, Sangkwon Han, Yoonseok Jung, Sunghoon Kwon |
Small |
20101206 |
| Target ID |
DDS, 4,4′-diaminodiphenylsulfone, extends organismic lifespan. |
107(45) |
19326-19331 |
Sung Chun Cho, Moon Cheol Park, Bhumsuk Keam, Jung Min Choi, Yunje Cho, Soonsil Hyun, Sang Chul Park, Junho Lee |
Proceedings of the National Academy of Sciences of the United States of America |
20101109 |
| Integration Core |
Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice. |
9(5) |
810-822 |
Young Sun Oh, Dae Gyu Kim, Gyuyoup Kim, Eung-Chil Choi, Brian K. Kennedy, Yousin Suh, Bum Joon Park, Sunghoon Kim |
Aging Cell |
20101009 |
| Integration Core |
Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation. |
397(1) |
100-105 |
Gyuyoup Kim, Jung Min Han, Sunghoon Kim |
Biochemical and Biophysical Research Communications |
20100618 |
| Integration Core |
Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus. |
15(4) |
358–366 |
Sang Gyu Park, Ho Seon Park, In-Kyong Jeong, Young Min Cho, Hong Kyu Lee, Young-Sun Kang, Sunghoon Kim, Kyong Soo Park |
Biomarkers |
20100601 |
| Integration Core |
Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs): a triad for cellular homeostasis. |
62(4) |
296-302 |
Sang Gyu Park, Eung-Chil Choi, Sunghoon Kim |
International Union of Biochemistry and Molecular Biology |
20100401 |
| Integration Core |
Identification of gp96 as a novel target for treatment of autoimmune disease in mice. |
5(3) |
e9792 |
Jung Min Han, Nam Hoon Kwon, Jin Young Lee, Seung Jae Jeong, Hee Jung Jung, Hyung Rae Kim, Zihai Li, Sunghoon Kim |
Plos One |
20100323 |
| Integration Core |
Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1 (AIMP1/p43). |
287(2) |
157-164 |
Jung Min Han, Heejoon Myung, Sunghoon Kim |
Cancer Letter |
20100128 |
| Integration Core |
A theoretical model for p53 dynamics: identifying optimal therapeutic strategy for its activation and stabilization. |
8(22) |
3707-3716 |
Do-Hyun Kim, Kyoohyoung Rho, Sunghoon Kim |
Cell Cycle |
20091115 |
| Integration Core |
MSC p43 required for axonal development in motor neurons. |
106(37) |
15944-15949 |
Xiaodong Zhu, Yang Liu, Yanqing Yin, Aiyun Shao, Bo Zhang, Sunghoon Kim, Jiawei Zhou |
Proceedings of the National Academy of Sciences of the United States of America |
20090915 |
| Integration Core |
Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis. |
30(9) |
1638-1644 |
Jin Woo Choi, Jung Yeon Um, Joydeb Kumar Kundu, Young-Joon Surh, Sunghoon Kim |
Carcinogenesis |
20090901 |
| Integration Core |
AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2. |
122(15) |
2710-2715 |
Jin Woo Choi, Dae Gyu Kim, Min Chul Park, Jung Yeon Um, Jung Min Han, Sang Gyu Park, Eung-Chil Choi, Sunghoon Kim |
Journal of Cell Science |
20090801 |
| Integration Core |
LysRS serves as a key signaling molecule in the immune response by regulating gene expression. |
34(5) |
603-611 |
Nurit Yannay-Cohen, Irit Carmi-Levy,Gillian Kay, Christopher Maolin Yang, Jung Min Han, D. Michael Kemeny, Sunghoon Kim, Hovav Nechushtan, Ehud Razin |
Molecular Cell |
20090612 |
| Integration Core |
2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. |
44(1) |
239-250 |
Farhanullah, Taehee Kang, Eun-Jung Yoon, Eun-Chil Choi, Sunghoon Kim, Jeewoo Lee |
European Journal of Medicinal Chemistry |
2009 |
| Integration Core |
The physiological role of lysyl tRNA synthetase in the immune system. |
103 |
1-27 |
Hovav Nechushtan, Sunghoon Kim, Gillian Kay, Ehud Razin |
Advances in Immunology |
2009 |
| Integration Core |
Aminoacyl tRNA synthetases and their connections to disease. |
105(32) |
11043-11049 |
Sang Gyu Park, Paul Schimmel, Sunghoon Kim |
Proceedings of the National Academy of Sciences of the United States of America |
20080812 |
| Integration Core |
AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53. |
105(32) |
11206-11211 |
Jung Min Han, Bum-Joon Park, Sang Gyu Park, Young Sun Oh, So Jung Choi, Sang Won Lee, Soon-Kyung Hwang, Seung-Hee Chang, Myung-Haing Cho, Sunghoon Kim |
Proceedings of the National Academy of Sciences of the United States of America |
20080812 |
| Integration Core |
AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2. |
371(3) |
395-400 |
Yeon Sook Lee, Jung Min Han, Sung Hwa Son, Jin Woo Choi, Eun Ju Jeon, Suk-Chul Bae, Young In Park, Sunghoon Kim |
Biochemical and Biophysical Research Communications |
20080704 |
| Integration Core |
Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM. |
283(20) |
14032-14040 |
Kyung-Jin Kim, Min Chul Park, So Jung Choi, Young Sun Oh, Eung-Chil Choi, Hyo Je Cho, Myung Hee Kim, Soo-Hyun Kim, Dong Wook Kim, Sunghoon Kim, Beom Sik Kang |
The Journal of Biological Chemistry |
20080516 |
| Integration Core |
AIMP1/p43 protein induces the maturation of bone marrow-derived dendritic cells with T helper type 1-polarizing ability. |
180(5) |
2894-2902 |
Kim, E., Kim, S. H., Kim, S., Cho, D., and Kim, T. S. |
The Journal of Immunology |
20080301 |
| Integration Core |
Aminoacyl-tRNA synthetase-interacting multi-functional protein 1/p43: an emerging therapeutic protein working at systems level. |
3(8) |
945-957 |
Sang Won Lee, Gyuyoup Kim, Sunghoon Kim |
Expert Opinion on Drug Discovery |
2008 |
| Integration Core |
Discovery of novel indazole-linked triazoles as antifungal agents. |
17(12) |
3486-3490 |
Joon Seok Park, Kyung A Yu, Tae Hee Kang, Sunghoon Kim, Young-Ger Suh |
Bioorganic & Medicinal Chemistry Letters |
20070615 |
| Integration Core |
Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases. |
170(6) |
2042-2054 |
Jung Min Han, Sang Gyu Park, Bei Liu, Bum-Joon Park, Jin Young Kim, Cheng He Jin, Yeong Wook Song, Zihai Li, Sunghoon Kim |
American Journal of Pathology |
20070601 |
| Integration Core |
Hierarchical network between the components of the multi-tRNA synthetase complex: implications for complex formation. |
281(50) |
38663-38667 |
Jung Min Han, Min Ji Lee, Sang Gyu Park, Sun Hee Lee, Ehud Razin, Eung-Chil Choi, Sunghoon Kim |
The Journal of Biological Chemistry |
20061215 |
| Integration Core |
Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors. |
14(21) |
7154-7159 |
Farhanullah, Su Yeon Kim, Eun-Jeong Yoon, Eung-Chil Choi, Sunghoon Kim, Taehee Kang, Farhana Samrin, Sadhna Purie, Jeewoo Lee |
Bioorganic & Medical Chemistry |
20061101 |
| Integration Core |
Hormonal activity of AIMP1/p43 for glucose homeostasis. |
103(40) |
14913-14918 |
Sang Gyu Park, Young Sun Kang, Jin Young Kim, Chang Seok Lee, Young Gyu Ko, Woo Je Lee, Ki-Up Lee, Young Il Yeom, Sunghoon Kim |
Proceedings of the National Academy of Sciences of the United States of America |
20061003 |
| Integration Core |
Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors. |
16(18) |
4898-4907 |
Su Yeon Kim, Yeon-Sook Lee, Taehee Kang, Sunghoon Kimb, Jeewoo Lee |
Bioorganic & Medicinal Chemistry Letters |
20060915 |
| Integration Core |
Do aminoacyl-tRNA synthetases have biological functions other than in protein biosynthesis? |
58(9) |
556-558 |
Sang Gyu Park, Sunghoon Kim |
IUBMB Life |
20060901 |
| Integration Core |
AIMP3 haploinsufficiency disrupts oncogene-induced p53 activation and genomic stability. |
66(14) |
6913-6918 |
Bum-Joon Park, Young Sun Oh, Seung Yong Park, So Jung Choi, Cornelia Rudolph, Brigitte Schlegelberger, Sunghoon Kim |
Cancer Research |
20060715 |
| Integration Core |
Antitumor activity of the novel human cytokine AIMP1 in an in vivo tumor model. |
21(2) |
213-217 |
Yeon-Sook Lee, Jung Min Han, Taehee Kang, Young In Park, Hwan Mook Kim, Sunghoon Kim |
Molecules and Cells |
20060430 |
| Integration Core |
Structural separation of different extracellular activities in aminoacyl-tRNA synthetase-interacting multi-functional protein, p43/AIMP1. |
342(1) |
113-118 |
Jung Min Han, Sang Gyu Park, Yeonsook Lee, Sunghoon Kim |
Biochemical and Biophysical Research Communications |
20060331 |
| Integration Core |
The novel cytokine p43 induces IL-12 production in macrophages via NF-kappaB activation, leading to enhanced IFN-gamma production in CD4+ T cells. |
176(1) |
256-264 |
Eugene Kim, Seung Hyun Kim, Sunghoon Kim, Tae Sung Kim |
The Journal of Immunology |
2006 |
| Integration Core |
Multi-functional proteins in tumorigenesis: Aminoacyl-tRNA synthetases and translational components. |
3(4) |
233-247 |
Sang Won Lee, Young Sun Kang, Sunghoon Kim |
Current Proteomics |
2006 |
| Integration Core |
Aminoacyl-tRNA synthetase-interacting multi-functional protein, p43, is imported to endothelial cells via lipid rafts. |
96(6) |
1286-1295 |
Jae-Sung Yi, Ji-Yeon Lee, Sung-Gil Chi, Ji-Hyun Kim, Sang Gyu Park, Sunghoon Kim, Young-Gyu Ko |
Journal of Cellular Biochemistry |
20051215 |
| Integration Core |
Inactivation of organellar glutamyl- and seryl-tRNA synthetases leads to developmental arrest of chloroplasts and mitochondria in higher plants. |
280(44) |
37098-37106 |
Yu-Kyung Kim, Jae-Yong Lee, Hye Sun Cho, Sang Sook Lee, Hyun Jung Ha, Sunghoon Kim, Doil Choi, Hyun-Sook Pai |
The Journal of Biological Chemistry |
20051104 |
| Integration Core |
Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers. |
30(10) |
569-574 |
Sang Gyu Park, Karla L. Ewalt, Sunghoon Kim |
Trends in Biochemical Sciences |
20051030 |
| Integration Core |
Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. |
25(35) |
7968-7978 |
Han Seok Ko, Rainer von Coelln, Sathya R. Sriram, Seong Who Kim, Kenny K. K. Chung, Olga Pletnikova, Juan Troncoso, Brett Johnson, Roya Saffary, Eyleen L. Goh, Hongjun Song, Bum-Joon Park, Min Jung Kim, Sunghoon Kim, Valina L. Dawson, Ted M. Dawson |
The Journal of Neuroscience |
20050831 |
| Integration Core |
Deoxyribosyl analogues of methionyl and isoleucyl sulfamate adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. |
15(14) |
3389-3393 |
Sung Eun Kim, Su Yeon Kim, Sunghoon Kim, Taehee Kang, Jeewoo Lee |
Bioorganic & Medicinal Chemistry Letters |
20050715 |
| Integration Core |
Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response. |
102(18) |
6356-6361 |
Sang Gyu Park, Hye Jin Kim, You Hong Min, Eung-Chil Choi, Young Kee Shin, Bum-Joon Park, Sang Won Lee, Sunghoon Kim |
Proceedings of the National Academy of Sciences of the United States of America |
20050503 |
| Integration Core |
The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. |
166(2) |
387-398 |
Sang Gyu Park, Hyosook Shin, Young Kee Shin, Yeonsook Lee, Eung-Chil Choi, Bum-Joon Park, Sunghoon Kim |
American Journal of Pathology |
20050201 |
| Integration Core |
The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. |
120(2) |
209-221 |
Bum-Joon Park, Jin Wook Kang, Sang Won Lee, So-Jung Choi, Young Kee Shin, Young Ha Ahn, Yun Hee Choi, Dongho Choi, Kwang Soo Lee, Sunghoon Kim |
Cell |
20050128 |
| Integration Core |
Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. |
119(2) |
195-208 |
Prabha Sampath, Barsanjit Mazumder, Vasudevan Seshadri, Carri A. Gerber, Laurent Chavatte, Michael Kinter, Shu M. Ting, J. David Dignam, Sunghoon Kim, Donna M. Driscoll, Paul L. Fox |
Cell |
20041015 |
| Integration Core |
Nuclear localization of aminoacyl-tRNA synthetases using single-cell capillary electrophoresis laser-induced fluorescence analysis. |
76(16) |
4741-4746 |
Nilhan Gunasekera, Sang Won Lee, Sunghoon Kim, Karin Musier-Forsyth, Edgar Arriaga |
Analytical Chemistry |
20040815 |
| Integration Core |
Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents. |
14(15) |
3881-3883 |
Sun-Young Jang, Young Hwan Ha,Seung Whan Ko, Wonku Lee, Jongkook Lee, Sunghoon Kim, Yong Woo Kim, Won Koo Lee, Hyun-Joon Ha |
Bioorganic & Medicinal Chemistry Letters |
20040804 |
| Integration Core |
Aminoacyl-tRNA synthetase complexes: beyond translation. |
117(17) |
3725-3734 |
Sang Won Lee, Byeong Hoon Cho, Sang Gyu Park, Sunghoon Kim |
Journal of Cell Science |
20040801 |
| Integration Core |
Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assembly. |
78(14) |
7553-7564 |
Rabih Halwani, Shan Cen, Hassan Javanbakht, Jenan Saadatmand, Sunghoon Kim, Kiyotaka Shiba, Lawrence Kleiman |
Journal of Virology |
20040701 |
| Integration Core |
Effect of solvent on the surface of protein chip plate. |
37(2) |
76-79 |
June Won Hyun, Mi Young Yun, S. M. An, S. J. Noh, Young-Duk Huh, Heonyong Park, Y. S. Song, Jaeho Pyee, K. R. Kim, S. Kim |
Journal of the Korean institute of surface engineering |
20040402 |
| Integration Core |
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase. |
11(2) |
149-156 |
Yoshiaki Kise, Sang Won Lee, Sang Gyu Park, Shuya Fukai, Toru Sengoku, Ryohei Ishii, Shigeyuki Yokoyama, Sunghoon Kim, Osamu Nureki |
Nature Structural & Molecular Biology |
20040201 |
| Integration Core |
Structure of the N-terminal extension of human aspartyl-tRNA synthetase: implications for its biological function. |
35(11) |
1548-1557 |
Hae-Kap Cheong, Jin-Young Park , Eun-Hee Kim , Chulhyun Lee , Sunghoon Kim , Youngsoo Kim , Byong-Seok Choi d , Chaejoon Cheong |
The International Journal of Biochemistry & Cell Biology |
20031101 |
| Integration Core |
Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. |
34(3) |
330-336 |
Min Jung Kim, Bum-Joon Park, Young-Sun Kang, Hyoung June Kim, Jae-Hyun Park, Jung Woo Kang, Sang Won Lee, Jung Min Han, Han-Woong Lee, Sunghoon Kim |
Nature Genetics |
20030701 |
| Integration Core |
Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43. |
542(1-3) |
119-124 |
Hee-Chul Ahn, Sunghoon Kim, Bong-Jin Lee |
FEBS Letters |
20030508 |
| Integration Core |
Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics. |
61(4) |
278-288 |
Kim S, Lee SW, Choi E-C, Choi SY |
Applied Microbiology and Biotechnology |
20030501 |
| Integration Core |
Molecular network and functional implications of macromolecular tRNA synthetase complex. |
303(4) |
985-993 |
Jung Min Han, Jin Young Kim, Sunghoon Kim |
Biochemical and Biophysical Research Communications |
20030418 |
| Integration Core |
In vitro development of resistance to a novel fluoroquinolone, DW286, in methicillin-resistant Staphylococcus aureus clinical isolates. |
51(4) |
1011-1016 |
Mi-Jeong Kim, Hee-Jeong Yun, Jin-Wook Kang, Sunghoon Kim, Jin-Hwan Kwak, Eung-Chil Choi |
Journal of Antimicrobial Chemotherapy |
20030401 |
| Integration Core |
Prevalence and mechanisms of low- and high-level mupirocin resistance in staphylococci isolated from a Korean hospital. |
51(3) |
619-623 |
Hee-Jeong Yun, Sang Won Lee, Gyu Man Yoon, Su Yeon Kim, Sooyoung Choi, Yeong Seon Lee, Sunghoon Kim |
Journal of Antimicrobial Chemotherapy |
20030301 |
| Integration Core |
Protein immobilization on plasma-polymerized ethylenediamine-coated glass slides. |
313(1) |
41-45 |
Jinmo Kim, Heonyong Park, Donggeun Jung, Sunghoon Kim |
Analytical Biochemistry |
20030201 |
| Integration Core |
A novel sol-gel method to produce the poly-L-lysine coated plate as a platform for protein chips. |
24(4) |
1-2 |
June Won Hyun, Shi Yong Kim, Sanghee Lee, Heonyong Park, Jaeho Pyee, Sunghoon Kim |
Bulletin of The Korean Chemical Society |
20030110 |
| Integration Core |
Retrovirus-specific packaging of aminoacyl-tRNA synthetases with cognate primer tRNAs. |
76(24) |
13111-13115 |
Shan Cen, Hassan Javanbakht, Sunghoon Kim, Kiyotaka Shiba, Rebecca Craven, Alan Rein, Karla Ewalt,Paul Schimmel, Karin Musier-Forsyth, Lawrence Kleiman |
Journal of Virology |
20021201 |
| Integration Core |
Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43. |
20(4) |
148-153 |
Heonyong Park, Sang Gyu Park, Junghee Kim, Young-Gyu Ko, Sunghoon Kim |
Cytokine |
20021124 |
| Integration Core |
Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis. |
277(47) |
45243-45248 |
Sang Gyu Park, Young-Sun Kang, Young Ha Ahn, Soon Hee Lee, Kwang-Rok Kim, Kyu-Won Kim, Gou Young Koh, Young-Gyu Ko, Sunghoon Kim |
The Journal of Biological Chemistry |
20021122 |
| Integration Core |
Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. |
277(46) |
44448-44454 |
Jooyoung Jung, Soon-Youl Lee, Sun Wook Hwang, Hawon Cho, Jieun Shin, Young-Sun Kang, Sunghoon Kim, Uhtaek Oh |
The Journal of Biological Chemistry |
20021115 |
| Integration Core |
Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. |
22(22) |
7721-7730 |
Hee-Sae Park, Ssang-Goo Cho, Chang Kyun Kim, Hyun Sub Hwang, Kyung Tae Noh, Mi-Sung Kim, Sung-Ho Huh, Myung Jin Kim, Kanghyun Ryoo, Eun Kyung Kim, Woo Jin Kang, Jae-Seon Lee, Jeong-Sun Seo,Young-Gyu Ko, Sunghoon Kim, Eui-Ju Choi |
Molecular and Cellular Biology |
20021101 |
| Integration Core |
Protein adsorption on the nickel-coated glass slide for protein chips. |
23(12) |
1-5 |
June Won Hyun, Shi Yong Kim, Sanghee Lee, Heonyong Park, Jaeho Pyee, Sunghoon Kim |
Bulletin of The Korean Chemical Society |
20020731 |
| Integration Core |
p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. |
99(12) |
7912-7916 |
Jin Young Kim, Young-Sun Kang, Joong-Won Lee, Hyoung June Kim, Young Ha Ahn, Heonyong Park, Young-Gyu Ko, Sunghoon Kim. |
Proceedings of the National Academy of Sciences of the United States of America |
20020611 |
| Integration Core |
Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation. |
277(10) |
8388-8394 |
Sun Young Chang, Sang Gyu Park, Sunghoon Kim, Chang-Yuil Kang |
The Journal of Biological Chemistry |
20020308 |
| Integration Core |
Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex. |
291(1) |
158-164 |
Jong Sang Lee, Sang Gyu Park, Heonyong Park, Wongi Seol, Sangwon Lee, Sunghoon Kim |
Biochemistry & Biophysical Research Communications |
20020215 |
| Integration Core |
Monocyte cell adhesion induced by a human aminoacyl-tRNA synthetase-associated factor, p43: identification of the related adhesion molecules and signal pathways. |
71(2) |
223-230 |
Heonyong Park, Sang Gyu Park, Taeho Kim, Gyuyoup Kim, Young-Gyu Ko, Sunghoon Kim |
Journal of Leukocyte Biology |
20020201 |
| Integration Core |
Novel regulatory interactions and activities of mammalian tRNA synthetases. |
2(9) |
1304-1310 |
Young-Gyu Ko, Heunyong Park, Sunghoon Kim |
Proteomics |
2002 |
| Integration Core |
Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm. |
276(42) |
39103-39106 |
Young-Gyu Ko,Young-Sun Kang, Heunyong Park, Wongi Seol, Jinyoung Kim,Taeho Kim, Hee-Sae Park, Eui-Ju Choi, Sunghoon Kim |
The Journal of Biological Chemistry |
20011019 |
| Integration Core |
A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes. |
276(25) |
23028-23033 |
Young-Gyu Ko, Heunyong Park, Taeho Kim, Joong-Won Lee, Sang Gyu Park, Wongi Seol, Jee Eun Kim, Won-Ha Lee, Se-Hwa Kim, Jeong-Euy Park, Sunghoon Kim |
The Journal of Biological Chemistry |
20010622 |
| Integration Core |
Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. |
11(8) |
965-968 |
Jeewoo Lee, Sanguk Kang, Suyeon Kim, Sungeun Kim, Yeongjoon Jo, Sunghoon Kim |
Bioorganic & Medicinal Chemistry Letters |
20010423 |
| Integration Core |
Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. |
11(8) |
961-964 |
Jeewoo Lee, Sanguk Kang, Suyeon Kim, Sungeun Kim Meekyoung Kang, Yeongjoon Jo, Sunghoon Kim |
Bioorganic & Medicinal Chemistry Letters |
20010423 |
| Integration Core |
Msx1 gene overexpression induces G1 phase cell arrest in human ovarian cancer cell line OVCAR3. |
281(5) |
1234-1240 |
Jinhee Park, Kyungsook Park, Sunghoon Kim, and Je-Ho Lee |
Biochemistry & Biophysical Research Communications |
20010301 |
| Integration Core |
Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. |
276(8) |
6030-6036 |
Young-gyu Ko, Enu-kyoung Kim, Taeho Kim, Heonyong Park, Hee-Sae Park, Eui-ju Choi, Sunghoon Kim |
The Journal of Biological Chemistry |
20010223 |
| Integration Core |
Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats. |
39(51) |
15775-15782 |
Eui-Jun Jeong, Geum-Sook Hwang, Kyung Hee Kim, Min Jung Kim, Sunghoon Kim, Key-Sun Kim |
Biochemistry |
20001226 |
| Integration Core |
Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. |
275(41) |
31682-31688 |
Jeongwoo Kang, Taeho Kim, Young-Gyu Ko, Seung Bae Rho, Sang Gyu Park, Min Jung Kim, Ho Jeong Kwon, Sunghoon Kim |
The Journal of biological chemistry |
20001013 |
| Integration Core |
A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases. |
275(35) |
27062-27068 |
Youngsoo Kim, Joongchul Shin, Rongbao Li, Chaejoon Cheong, Kyounghee Kim, Sunghoon Kim |
The Journal of biological chemistry |
20000901 |
| Integration Core |
An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing. |
28(15) |
2866-2872 |
Jee Eun Kim, Kyoung-Hee Kim, Sang Won Lee, Wongi Seol, Kiyotaka Shiba, Sunghoon Kim |
Nucleic Acids Research |
20000801 |
| Integration Core |
Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex. |
275(28) |
21768-21772 |
Taeho Kim, Sang Gyu Park, Jee Eun Kim, Wongi Seol, Young-Gyu Ko, Sunghoon Kim |
The Journal of biological chemistry |
20000714 |
| Integration Core |
Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. |
149(3) |
567-574 |
Young Gyu Ko, Young-Sun Kang, Eun-Kyoung Kim, Sang Gyu Park, Sunghoon Kim |
The Journal of Cell Biology |
20000501 |
| Integration Core |
Death effector domain of a mammalian apoptosis mediator, FADD, induces bacterial cell death. |
35(6) |
1540-1549 |
Sang Won Lee, Young Gyu Ko, SookHee Bang, Key-Sun Kim, Sunghoon Kim |
Molecular Microbiology |
20000301 |
| Integration Core |
Methionine analogue probes functionally important residues in active site of methionyl-tRNA synthetase. |
32(6) |
547-553 |
Young Joon Jo, Sang Won Lee, Myung Kyun Jo, Jee Woo Lee, Mee-Kyoung Kang, Jeong Hyeok Yoon, Sunghoon Kim |
BMB Reports (Journal of Biochemistry and Molecular Biology) |
19991101 |
| Integration Core |
Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase. |
274(24) |
16673-16676 |
Sang Gyu Park, Keum Hee Jung, Jong Sang Lee, Yeong Joon Jo, Hiromi Motegi, Sunghoon Kim, Kiyataka Shiba. |
The Journal of Biological Chemistry |
19990611 |
| Integration Core |
Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase. |
9(10) |
1365–1370 |
Jeewoo Lee, Sang Uk Kang, Mee Kyoung Kang, Moon Woo Chun, Yeong Joon Jo, Jin Hwan Kkwak, Sunghoon Kim |
Bioorganic & Medicinal Chemistry Letters |
19990517 |
| Integration Core |
Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex. |
96(8) |
4488-4493 |
Seung Bae Rho, Min Jung Kim, Jong Sang Lee, Wongi Seol, Hiromi Motegi, Sunghoon Kim, Kiyotaka Shiba |
Proceedings of the National Academy of Sciences of the United States of America |
19990413 |
| Integration Core |
Methionine analogues as inhibitors of methionyl-tRNA synthetase. |
8(24) |
3511-3514 |
Jeewoo Lee, Mee Kyoung Kang, Moon Woo Chun, Yeong Joon Jo, Jin Hwan Kwak, Sunghoon Kim |
Bioorganic Medicinal Chemistry Letters |
19981215 |
| Integration Core |
Cloning and characterization of mitochondrial methionyl-tRNA synthetase from a pathogenic fungi Candida albicans. |
215(2) |
311-318 |
Sang Won Lee, Yeong Joon Jo, Sunghoon Kim |
Gene |
19980730 |
| Integration Core |
Biochemical and phylogenetic analyses of methionyl-tRNA synthetase isolated from a pathogenic microorganism, Mycobacterium tuberculosis. |
427(2) |
259-262 |
Sunghoon Kim, Yeong Joon Jo, Sang Ho Lee, Hiromi Motegi, Kiyataka Shiba, Mandana Sassanfar and Susan A. Martinis |
FEBS Letters |
19980508 |
| Integration Core |
A multifunctional repeated motif is present in human bifunctional tRNA synthetase. |
273(18) |
11267-11273 |
Seung Bae Rho, Jong Sang Lee, Eui Jun Jeong, Key Sun Kim, Yang Gyun Kim, Sunghoon Kim |
The Journal of biological chemistry |
19980501 |
| Integration Core |
Abnormal proteins enhance stress-induced cell death. |
243(1) |
153-157 |
Se Jin Kim, Sunghoon Kim |
Biochemistry & Biophysical Research Communications |
19980204 |
