| Integration Core |
Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors. |
59(22) |
10322-10328 |
Suyoung Yoon, Jong Hyun Kim, Sung-Eun Kim, Changhoon Kim, Phuong-Thao Tran, Jihyae Ann, Yura Koh, Jayun Jang, Sungmin Kim, Hee-sun Moon, Won Kyung Kim, Sangkook Lee, Jiyoun Lee, Sunghoon Kim, Jeewoo Lee |
Journal of Medicinal Chemistry |
20161123 |
| Drug Screening |
A chemical biology route to site-specific authentic protein modifications. |
354(6312) |
623-626 |
Aerin Yang, Sura Ha, Jihye Ahn, Rira Kim, Sungyoon Kim, Younghoon Lee, Jaehoon Kim, Dieter Söll, Hee-Yoon Lee, Hee-Sung Park |
Science |
20161104 |
| Integration Core |
Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity |
17(11) |
1252-1262 |
Lee EY, Lee HC, Kim HK, Jang SY, Park SJ, Kim YH, Kim JH, Hwang J, Kim JH, Kim TH, Arif A, Kim SY, Choi YK, Lee C, Lee CH, Jung JU, Fox PL, Kim S, Lee JS, Kim MH |
Nature Immunology |
20161101 |
| Integration Core |
Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection. |
2 |
16191 |
Ahn YH, Park S, Choi JJ, Park BK, Rhee KH, Kang E, Ahn S, Lee CH, Lee JS, Inn KS, Cho ML, Park SH, Park K, Park HJ, Lee JH, Park JW, Kwon NH, Shim H, Han BW, Kim P, Lee JY, Jeon Y, Huh JW, Jin M, Kim S |
Nature Microbiology |
20161017 |
| Integration Core |
O-GlcNAcylation of orphan nuclear receptor ERRγ promotes hepatic gluconeogenesis. |
65(10) |
2835-2848 |
Jagannath Misra, Don-Kyu Kim, Yoon Seok Jung, Han Byeol Kim, Yong-Hoon Kim, Eun-Kyung Yoo, Byung Gyu Kim, Sunghoon Kim, In-Kyu Lee, Robert A. Harris, Jeong-Sun Kim, Chul-Ho Lee, Jin Won Cho, Hueng-Sik Choi |
Diabetes |
20161001 |
| Integration Core |
Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling. |
16(9) |
1510–1517 |
Mee-Sup Yoon, Kook Son, Edwin Arauz, Jung Min Han, Sunghoon Kim, Jie Chen |
Cell Reports |
20160809 |
| Integration Core |
AIMP2 controls intestinal stem cell compartments and tumorigenesis by modulating Wnt/β-catenin signaling. |
76(15) |
4559-4568 |
Min Kyu Yum, Jong-Seol Kang, Al-Eum Lee, Young-Woo Jo, Ji Yun Seo, Hyun-A Kim, Yoon-Young Kim, Jinwoo Seong, Eun Byul Lee, Ji-Hoon Kim, Jung Min Han, Sunghoon Kim, Young-Yun Kong |
Cancer Research |
20160801 |
| Integration Core |
Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor Suppressive Interaction with Smurf2. |
76(11) |
3422-3436 |
Dae Gyu Kim, Jin Young Lee, Ji-Hyun Lee, Ha Yeon Cho, Beom Sik Kang, Song-Yee Jang, Myung Hee Kim, Min Guo, Jung Min Han, Seong-Jin Kim, Sunghoon Kim |
Cancer Research |
20160701 |
| Integration Core |
Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase(LRS)-targeted mTORC1 inhibitor. |
26(13) |
3038-3041 |
Suyoung Yoon, Jong Hyun Kim, Ina Yoon, Changhoon Kim, Sung-Eun Kim, Yura Koh, Seung Jae Jeong, Jiyoun Lee, Sunghoon Kim, Jeewoo Lee |
Bioorganic & Medicinal Chemistry Letters |
20160701 |
| Integration Core |
Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell‑extracellular matrix adhesion for migration. |
48(4) |
1553-1560 |
Seo Hee Nam, Minkyung Kang, Jihye Ryu, Hye-Jin Kim, Doyeun Kim,Dae Gyu Kim, Nam Hoon Kwon, Sunghoon Kim, Jung Weon Lee |
International Journal of Oncology |
20160401 |
| Integration Core |
Novel morphological and genetic analysis of cancer cells in a 3D microenvironment identifies STAT3 as a regulator of tumor permeability barrier function. |
76(5) |
1044-1054 |
Min Chul park, Hyobin Jeong, Sung Hwa Son, Younha Kim, Daeyoung Han, Peter C. Goughnour, Taehee Kang, Nam Hoon Kwon, Hyo Eun Moon, Sun Ha Paek, Daehee Hwang, Ho Jun Seol, Do-Hyun Nam, Sunghoon Kim |
Cancer Research |
20160301 |
