Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity

Eun-Young Lee, Hyun-Cheol Lee, Hyun-Kwan Kim, Song Yee Jang, Seong-Jun Park, Yong-Hoon Kim, Jong Hwan Kim, Jungwon Hwang, Jae-Hoon Kim, Tae-Hwan Kim, Abul Arif, Seon-Young Kim, Young-Ki Choi, Cheolju Lee, Chul-Ho Lee, Jae U Jung, Paul L Fox, Sunghoon Kim, Jong-Soo Lee & Myung Hee Kim


The mammalian cytoplasmic multi-tRNA synthetase complex (MSC) is a depot system that regulates non-translational cellular functions. Here we found that the MSC component glutamyl-prolyl-tRNA synthetase (EPRS) switched its function following viral infection and exhibited potent antiviral activity. Infection-specific phosphorylation of EPRS at Ser990 induced its dissociation from the MSC, after which it was guided to the antiviral signaling pathway, where it interacted with PCBP2, a negative regulator of mitochondrial antiviral signaling protein (MAVS) that is critical for antiviral immunity. This interaction blocked PCBP2-mediated ubiquitination of MAVS and ultimately suppressed viral replication. EPRS-haploid (Eprs+/−) mice showed enhanced viremia and inflammation and delayed viral clearance. This stimulus-inducible activation of MAVS by EPRS suggests an unexpected role for the MSC as a regulator of immune responses to viral infection.

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