Technology Description and Features MoA ● Cellular internalization ● Cytosolic localization by endosomal escape ● Specific binding to the targeted cytosolic ● protein involved in PPI ● PPI interference ● Drug effects Lead ● Ras targeting iMab : cannot be further disclosed (under patent preparation) Indication ● Cancers ● Particularly colon/pancreatic cancers with ~60% K-Ras mutants
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Full-length IgG antibodies cannot cross cell membranes of living cells; this limits their use for direct targeting of cytosolic proteins. However disease-associated protein–protein interactions (PPIs) occur mainly in the cytosol of cells. We are now developing an innovative technology, called iMab (internalizing & PPI (protein-protein interaction) interfering antibody). iMab technology enables full-length IgG antibodies to directly target cytosolic proteins. It
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