제품 Short Description 이 표시됨
Tag Archive for: panning
Antibody Library Panning at Biocon: Solution for fully human antibody generation
BIOCON, 2016.06.01, biocon, fully, library, panning, solution, 0Technology Description and Features OPAL library Fully synthetic, human scFv library with six diversified CDRs CDR diversification by degenerate oligonucleotides, reflecting naturally occurring amino acids at each position Single framework design for easy sequence manipulation, uniformly high expression level and stability Validated on 100s of antigens: proteins, peptides, and small molecules In active use by >20 labs and companies OPAL-S Library Fully synthetic, human scFv library with improved CDR design Non-combinatorial CDR diversity designed to emulate naturally produced CDR sequences Higher humanness of CDR sequences compared to conventionally designed libraries Better developability without undesirable PTM motifs Validated by NGS and panning against multiple antigens Panning Utilization of two highly functional libraries for successful antibody isolation Parellel panning on same targets using multiple panning strategies maximizes the clonal diversity Panning on passively adsorbed or biotinylated antigens, whole cells expressing membrane protein antigen, etc. Antigen design based on target structure, desired epitope, and antigenicity