Halofuginone was used in a clinical trial for cancer and fibrotic diseases. It was found to bind to tRNA and
it targets the active site of PRS and regulates its vitality. The article about Halofuginone was published in Nature under the title, “ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.”
Go to http://www.biocon.re.kr/33108 for more details.