2024
AIMP1-derived peptide secreted from hair follicle stem cells promotes hair growth through activating dermal papilla cells. YounHa Kim, Sang Bum Kim, Ho Lee, Doyeun Kim, Soon Sun Bak, Ina Yoon, Seongmin Cho, Seung Jae Jeong, Yoon Jeon, Jangwoo Lee, Ji-hee Kim, Soohwan Oh, Khas-Erdene Battogtokh, Min Chul Park, Young Kwan Sung, Sunghoon Kim
Early onset diagnosis in Alzheimer’s disease patients via amyloid-β oligomers-sensing probe in cerebrospinal fluid. Kim JS, An JS, Kim KH, Lim HJ, Kim HY, Shin JW, Park IW, Cho IH, Kim HY, Kim S, McLean C, Choi KY, Kim YS, Lee KH, Nat Commun., in press, 2024
Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis. Kim YT, Huh JW, Choi YH, Yoon HK, Nguyen TT, Chun EH, Jeong GY, Park SY, Ahn SWm Lee WJ, Noh YW, Lee KS, Ahn HS, Lee CJ, Lee SM, Kim KS, Suh GJ, Jeon KM, Kim S, Jin MR, EMBO Mol Med. 16:40, 2024
2023
Prediction of prognosis in pancreatic cancer according to Methionyl-tRNA synthetase 1 expression as determined by immunohistochemical Staining. Jang SI, Nahm JH, Lee SY, Cho JH, Do MY, Park JS, Lee HS, Yang JY, Kong JW, Jung SH, Kim S, Lee DK, Cancers, 15:5413, 2023
Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis. EMBO Mol Med., in press, 2023
Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis. Kim SM, Park SH, Hwang SH, Lee EY, Kim JH. Lee GS, Lee GJ, Chang DH, Lee JG, Hwang JW, Lee YG, Kyung MS, Kim EK, Kim JH, Kim TH, Moon KH, Kim BC, Ko GP, Kim SY, Ryu JH, Lee JS, Lee CH, Kim JY, Kim S, Lee WJ, Kim MH, Cell Host Microbe., 29: S1931, 2023
Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1. Yoon I, Kim SH, Cho MJ, You KA, Son JH, Lee C, Suh JH, Bae DJ, Kim JM, Oh S, Park SH, Kim SA, Cho SH, Park SH, Bang KH, Seo MJ, Kim JH, Lee BY, Park JS, Hwang KY, Kim S, EMBO Mol Med. 22:e16940, 2023
EPRS1 Controls the TGF- β Signaling Pathway via Interaction with TβRI in Hepatic Stellate Cell. Yoon I, Song JA, Suh JH, Kim SH, Son JH, Kim JH, Jang SY, Hwang KY, Kim MH, Kim S, Mol Cell Biol., 43: 223, 2023
Anti‑apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1‑Induced Neuronal Cell Death. Kook MG, Byun MR, Lee SM, Lee MH, Lee DH, Lee HB, Lee EJ, Baek KH, Kim S, Kang KS, Choi JW, Mol Neurobiol., 60:145, 2023
Tryptophan-dependent control of tryptophanyl-tRNA synthetase secretion pathways: Pathophysiological implications for innate immune responses.
Tram T. T. Yun N, Choi YH, Lee WK, Ji YJ, Chun EH, Kim YH, Lee JE, Jung HS, Kim S, Jin MR, Cell Rep.. 42:111905, 2023
2022
Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase.
Chung SS, Kang MS, Alimbetov D, Mun GI, Yunn NO, Kim YJ, Kim BG, Wie MW, Lee EA, Ra JS, Oh Jm, Lee DH, Lee KD , Kim JH, Han SH, Kim KT, Chung WK, Nam KH, Park JH, LEE BH, Kim S, Zhao W, Ryu SH, Lee YS, Myung KJm Cho YJ, Nat Commun., 13:6732, 2022
Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling.
Lee EY, Kim SM, Hwang JH, Jang SY, Park S, Choi S, Lee GS, Hwang J, Moon JH, Fox P, Kim S, Lee CH, Kim MH, Nat Commun., 13:6455, 2022
Synthesis and discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug.
Lee BR, Kim DG, Lee AR, Kim YM, Cui L, Kim S, Choi IH, J Enzyme Inhib Med Chem., 38:51, 2022
Ultra-Thin membrane filter with a uniformly arrayed nanopore structure for nanoscale separation of extracellular vesicles without cake formation.
Kim DS, Lee JH, Kim BY, Shin YJ, Park JH, Lee MB, Kim SB, Kim S, Nanoscale Adv., 5:640, 2022
Discovery of benzodioxane analogues as lead candidates of AIMP2-DX2 inhibitors.
Lee BR, Kim DG, Kim YM, Kim S, Choi IH, Bioorg Med Chem Lett.., 13:128889, 2022
O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.
Kim KB, Yoo HC, Kim BG, Kim SH, Sung YS, Yoon I, Yu YC, Park SJ, Kim JH, Myung K, Hwang KY, Kim S, Han JM, Nat Commun., 13: 2904, 2022
Two distinct receptor-binding domains of human glycyl-tRNA synthetase 1 displayed on extracellular vesicles activate M1 polarization and phagocytic bridging of macrophages to cancer cells.
Park MC, Goughnour P C, Jun Sm Cho SM, Song EJ, Kim SB, Kim HY, Hyun JK, Kim PH, Jung HS, Kim S, Cancer Lett, 539:215698, 2022
AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.
Kim D, Choi Y, Lee Y, Lim S, Kong J, Song JH, Roh Y, Harmalkar D, Lee K, Goo JI, Cho HY, Mushtaq AU, Lee J, Park SH, Kim D, Min BS, Lee KY, Jeon YH, Lee S, Lee K, Kim S, Nat Commun, 13:2572, 2022
Functional and pathologic association of aminoacyl-tRNA synthetases with cancer.
Sung Y, Yoon I, Han JM, Kim S, Exp Mol Med, 54:553, 2022
2021
Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2-Depleted Splice Variant of Aminoacyl-Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70((S)). Kim DG, Huddar S, Lim SM, Kong JW, Lee Y, Park CM, Lee SB, Suh YG, Kim MK, Lee K, Lee SK, Kim S. J Pharmacol Exp Ther., 379:358, 2021
Diffusion-Based Separation of Extracellular Vesicles by Nanoporous Membrane Chip.
Kim GJ, Park MC, Jang S, Han DY, Kim HJ, Kim WJ, Chun HG, Kim S. Biosensors, 11:347, 2021
Protocol for improving diffraction quality of leucyl-tRNA synthetase 1 with methylation and post-crystallization soaking and cooling in cryoprotectants.
Kim SH, Yoon I, Kim S, Hwang KY, STAR Protoc. 2:100642, 2021
Structural basis for the dynamics of human methionyl-tRNA synthetase in multi-tRNA synthetase complexes.
Kim DK, Lee HJ, Kong JW, Cho HY, Kim S, Kang BS, Nucleic Acids Res, 49:6549, 2021
Clinical Utility of Methionyl-tRNA Synthetase 1 Immunostaining in Cytologic Brushings of Indeterminate Biliary Strictures:
A Multicenter Prospective Study, Jang SI, Nahm JH, Kwon NH, Jeong S, Lee TH, Cho JH, Kwon CI, Kin DU, Kim JM, Cho HD, Lee HS, Kim S, Lee DK, Gastrointest Endosc, S0016-5107(21)01324-9, 2021
Role of tRNAs in Breast Cancer Regulation.
Kwon NH, Lee JY, Kim S, Adv Exp Med Biol.1187:121, 2021
Structure-based modification of pyrazolone derivatives to inhibit mTORC1 by targeting the leucyl-tRNA synthetase-RagD interaction.
Kim JH, Jung KS, Lee CH, Song D, Kim KB, Yoo HC, Park SJ, Kang JS, Lee KR, Kim S, Ham JM, Han GH, Bioorg Chem., 112: 104907, 2021
Discovery of Novel Potent Migrastatic Thiazolo[5,4-b]pyridines Targeting Lysyl-tRNA Synthetase (KRS) for Treatment of Cancer Metastasis.
Lee SB, Kwon NH, Seo BK, Lee JY, Cho HY, Kim KJ, Kim HS, Jung K, Jeon YH, Kim S, Suh YG, Eur J Med Chem. 218:113405, 2021
Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.
Kim S, Yoon I, Son JH, Park J, Kim KB, Lee JH, Park SY, Kang BS, Han JM, Hwang KY, Kim S, Cell Rep. 35:109031, 2021
Aminoacyl-tRNA synthetases and amino acid signaling.
Yu AC, Han JM, Kim S. Biochim Biophys Acta Mol Cell Res, 1868: 118889, 2021
2020
Amyloid-like oligomerization of AIMP2 contributes to a-synuclein interaction and Lewy-like inclusion.
Ham S, Yun SP, Kim H, Kim DH, Seo BA, Kim HJ, Shin JY, Dar MA, Lee GH, Yun IL, Kim D, Kim S, Kweon HS, Shin JH, Ko Han Seok, Lee Yj. Sci Transl Med, 12: eaax0091, 2020
Extracellular vesicles derived from macrophage display glycyl-tRNA synthetase 1 exhibits anti-cancer activity.
Goughnour PC, Park MC, Kim SB, Jun S, Yang WS, Chae S, Cho S, Song C, Lee JH, Hyun JK, Kim BG, Hwang D, Jung HS, Gho YS, Kim S. J Extracell Vesicles, 10: e12029, 2020
Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer.
Ku J, Kim R, Kim D, Song S, Lee K, Lee N, Kim M, Yoon SS, Kwon NH, Kim S, Kim Y, Koh Y. Comms Biol, 3: 630, 2020
Cell-based analysis of pairwise interactions between the components of the multi-tRNA synthetase complex.
Kong JW, Kim S. FASEB J, 34: 10476, 2020
Anticancer activity of pyrimethamine via ubiquitin mediated degradation of AIMP2‐DX2.
Kim DG, Park CM, Huddar S, Lim S, Kim S, Kim SK. Molecules, 25: 2763, 2020
An isoform of the oncogenic splice variant AIMP2-DX2 detected by a novel monoclonal antibody.
Kim DG, Nguyen TTH, Kwon NH, Sung J, Lim S, Kang EJ, Lee J, Seo WY, Kim A, Chang YS, Shim H & Kim S. Biomolecules, 10: 820, 2020
2-Aminophenylpyrimidines as novel inhibitors of aminoacyl-tRNA synthetase interacting multifunctional protein 2 (AIMP2)-DX2 for lung cancer treatment.
Lee S, Kim DG, Kim K, Kim T, Lim S, Kong H, Kim S, Suh YG. J Med Chem, 63: 3908, 2020
Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA synthetase 1.
Cho S, Kim SB, Lee Y, Song EC, Kim U, Kim HY, Suh JH, Goughnour PC, Kim YH, Yoon I, Shin NY, Kim D, Kim IK, Kang CY, Jang SY, Kim MH, Kim S. J Immunother Cancer, 8:e000277, 2020
Synthesis and structure-activity relationships of arylsulfonamides as AIMP2-DX2 inhibitors for the development of a novel anticancer therapy.
Sivaraman A, Kim DG, Bhattarai D, Kim M, Lee HY, Lim S, Kong J, Goo JI, Shim S, Lee S, Suh YG, Choi Y, Kim S, Lee K. J Med Chem, 63: 5139, 2020
Plasma lysyl-tRNA synthetase 1 (KARS1) as a novel diagnostic and prognostic biomarker for colorectal cancer.
Suh JH, Park MC, Peter G, Min BS, Kim SB, Lee WY, Cho YB, Cheon JH, Lee KY, Nam DH, Kim S. J Clin Med, 9: 533, 2020
Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1.
Yoon I, Nam M, Kim HK, Moon HS, Kim S, Jang J, Song JA, Jeong SJ, Kim SB, Cho S, Kim Y, Lee J, Yang WS, Yoo HC, Kim K, Kim MS, Yang A, Cho K, Park HS, Hwang GS, Hwang KY, Han JM, Kim JH, Kim S. Science, 367: 205, 2020
PHD1 controls muscle mTORC1 in a hydroxylation independent manner by stabilizing leucyl tRNA synthetase.
D’Hulst G, Soro-Arnaiz I, Masschelein E, Veys K, Fitzgerald G, Smeuninx B, Kim S, Deldicque L, Blaauw B, Carmeliet P, Breen L, Koivunen P, Zhao SM, De Bock K. Nat Commun, 11: 174, 2020
Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.
Lim S, Cho HY, Kim DG, Roh Y, Son SY, Mushtaq AU, Kim M, Bhattarai D, Sivaraman A, Lee Y, Lee J, Yang WS, Kim HK, Kim MH, Lee K, Jeon YH, Kim S. Nat Chem Biol, 16: 31, 2020
2019
ERK-dependent phosphorylation of the linker and substrate-binding domain of HSP70 increases folding activity and cell proliferation.
Lim S, Kim DG, Kim S. Exp Mol Med, 51: 1, 2019
Methionyl-tRNA synthetase is a useful diagnostic marker for lymph node metastasis in non-small cell lung cancer.
Lee JM, Kim T, Kim EY, Kim A, Lee DK, Kwon NH, Kim S, Chang YS. Yonsei Med J, 60: 1005, 2019
Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase.
Jobin PG, Solis N, Machado Y, Bell PA, Kwon NH, Kim S, Overall CM, Butler GS. J Biol Chem, 294: 12866, 2019
Symmetric assembly of a decameric subcomplex in human multi-tRNA synthetase complex via interactions between glutathione transferase-homology domains and aspartyl-tRNA synthetase.
Cho HY, Lee HJ, Choi YS, Kim DK, Jin KS, Kim S, Kang BS. J Mol Biol, 19: 30522, 2019
The DRS-AIMP2-EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex.
Hahn HG, Park SH, Kim HJ, Kim S, Han BW. IUCrJ, 6: 958, 2019
Aminoacyl-tRNA synthetases as therapeutic targets.
Kwon NH, Fox PL, Kim S. Nat Rev Dug Discov, 18: 629, 2019
Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration.
Son K, You JS, Yoon MS, Dai C, Kim JH, Khanna N, Banerjee A, Martinis SA, Han G, Han JM, Kim S, Chen J. J Clin Invest, 129: 2088, 2019
A threonyl-tRNA synthetase-mediated translation initiation machinery.
Jeong SJ, Park S, Nguyen LT, Hwang J, Lee EY, Giong HK, Lee JS, Yoon I, Lee JH, Kim JH, Kim HK, Kim D, Yang WS, Kim SY, Lee CY, Yu K, Sonenberg N, Kim MH, Kim S. Nat Commun, 10: 1357, 2019
Glycoprotein 96 polymorphisms are associated with the risk of systemic lupus erythematosus: A case‐control study.
Lee JS, Im CH, Lee SJ, Choi JY, Han JM, Kim S, Kim DJ, Park T, Lee EY, Song YW. Int J Rheum Dis, 22: 905, 2019
Evolution of the multi-tRNA synthetase complex and its role in cancer.
Hyeon DY, Kim JH, Ahn TJ, Cho Y, Hwang D, Kim S. J Biol Chem, 294: 5340, 2019
Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).
Yoon S, Kim SE, Kim JH, Yoon I, Tran PT, Ann J, Kim C, Byun WS, Lee S, Kim S, Lee J, Lee J. Bioorg Med Chem, 27: 1099, 2019
HIF1α‐mediated AIMP3 suppression delays stem cell aging via the induction of autophagy.
Kim C, Park JM, Song Y, Kim S, Moon J. Aging Cell, 18: e12909, 2019
Released tryptophanyl-tRNA synthetase stimulates innate immune responses against viral infection.
Lee HC, Lee ES, Uddin MB, Kim TH, Kim JH, Chathuranga K, Chathuranga WAG, Jin M, Kim S, Kim CJ, Lee JS. J Virol, 93: e01291, 2019
Glutamyl-prolyl-tRNA synthetase induces fibrotic extracellular matrix via both transcriptional and translational mechanisms.
Song DG, Kim D, Jung JW, Nam SH, Kim JE, Kim HJ, Kim JH, Lee SJ, Pan CH, Kim S, Lee JW. FASEB J, 33: 4341, 2019
Tumor suppressor miRNA-204-5p regulates growth, metastasis, and immune micro environment remodeling in breast cancer.
Hong BS, Ryu HS, Kim N, Kim J, Lee E, Moon H, Kim KH, Jin MS, Kwon NH, Kim S, Kim D, Chung DH, Jeong K, Kim K, Kim KY, Lee HB, Han W, Yun J, Kim JI, Noh DY, Moon HG. Cancer Res, 79: 1520, 2019
2018
Glutamyl-prolyl-tRNA synthetase regulates epithelial expression of mesenchymal markers and extracellular matrix proteins: implications for idiopathic pulmonary fibrosis.
Song DG, Kim D, Jung JW, Nam SH, Kim JE, Kim HJ, Kim JH, Pan CH, Kim S, Lee JW. Front Pharmacol, 9: 1337, 2018
AIMP3 deletion induces acute radiation syndrome-like phenotype in mice.
Kim D, Kim SM, Oh YS, Park SH, Jeon Y, Kim H, Lee H, Kim S. Sci Rep, 8: 15025, 2018
Biocon’s target factory.
Neenan TX, Burrier RE, Kim S. Nat Biotechnol, 36: 791, 2018
Lysyl-tRNA synthetase-expressing colon spheroids induce M2 macrophage polarization to promote metastasis.
Nam SH, Kim D, Lee D, Lee HM, Song DG, Jung JW, Kim JE, Kim HJ, Kwon NH, Jo EK, Kim S, Lee JW. J Clin Invest, 128: 5034, 2018
AIMP3 depletion causes genome instability and loss of stemness in mouse embryonic stem cells.
Kim SM, Jeon Y, Kim D, Jang H, Bae JS, Park MK, Kim H, Kim S, Lee H. Cell Death Dis, 9: 972, 2018
Exosomal secretion of truncated cytosolic lysyl-tRNA synthetase induces inflammation during cell starvation.
Kim SB, Cho S, Kim S. Cell Stress, 2: 119, 2018
Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity.
Park JS, Park MC, Lee KY, Goughnour PC, Jeong SJ, Kim HS, Kim HJ, Lee BJ, Kim S, Han BW. Int J Biol Macromol, 120: 835, 2018
Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Yoon S, Zuo D, Kim JH, Yoon I, Ann J, Kim SE, Cho D, Kim WK, Lee S, Lee J, Kim S, Lee J. Bioorg Med Chem, 26: 4073, 2018
Liposomal borrelidin for treatment of metastatic breast cancer.
Jeong M, Kim H, Kim S, Park JH. Drug Deliv Transl Res, 8: 1380, 2018
Aminoacyl-tRNA synthetases, therapeutic targets for infectious diseases.
Lee EY, Kim S, Kim MH. Biochem Pharmacol, 154: 424, 2018
Coordination of leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase for the mTORC1 signaling pathway.
Lee M, Kim JH, Yoon I, Lee C, Fallahi-Sichani M, Kang JS, Kang J, Guo M, Lee KY, Han G, Kim S, Han JM. Proc Natl Acad Sci U S A, 115: E5279, 2018
Stabilization of cyclin dependent kinase 4 by methionyl-tRNA synthetase in p16INK4a-negative cancer.
Kwon NH, Lee JY, Ryu YL, Kim C, Kong J, Oh S, Kang BS, Ahn HW, Ahn SGm Jeong J, Kim HK, Kim JH, Han DY, Park MC, Kim D, Takase R, Masuda I, Hou YM, Jang SI, Chang YS, Lee DK, Kim Y, Wang MW, Basappa, Kim S. ACS Pharmacol Transl Sci, 1: 21, 2018
AIMp1 Potentiates TH1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity.
Liang D, Tian L, You R, Halpert MM, Konduri V, Yunyu C. Baig, Paust S, Kim D, Kim S, Jia F, Huang S, Zhang X, Kheradmand F, Corry DB, Gilbert BE, Levitt JM and Decker WK. Front Immunol, 8: 1801, 2018
Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration.
Jeong SJ, Kim JH, Lim BJ, Yoon I, Song JA, Moon HS, Kim D, Lee DK, Kim S. Exp Mol Med, 50: e424., 2018
High-Throughput screening for protein synthesis inhibitors targeting aminoacyl-tRNA synthetases.
Kong J, Fang P, Madoux F, Spicer TP, Scampavia L, Kim S, Guo M. SLAS Discov, 23: 174, 2018
Transfer RNA-mediated enhancement of RSK/MSK signaling for cell proliferation.
Kwon NH, Lee MR, Kong J, Park SK, Hwang BJ, Kim BG, Lee ES, Moon HG, Kim S. RNA Biol, 15: 635, 2018
2017
Production of recombinant human procollagen type I C-terminal propeptide and establish-ment of a sandwich ELISA for quantification.
Seo WY, Kim JH, Baek DS, Kim SJ, Kang S, Yang WS, Song JA, Lee MS, Kim S, Kim YS. Sci Rep, 7: 15946, 2017
Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Yoon S, Kim JH, Koh Y, Tran PT, Ann J, Yoon I, Jang J, Kim WK, Lee S, Lee J, Kim S, Lee J. Bioorg Med Chem, 25: 4145, 2017
Control of leucine-dependent mTORC1 pathway through chemical intervension of leucyl-tRNA synthetase and RagD GTPase interaction.
Kim JH, Lee CH, Lee M, Wang H, Kim K, Park SJ, Yoon I, Jang JY, Zhao H, Kim HK, Kwon NH, Jeong SJ, Yoo HC, Kim JH, Yang JS, Lee MY, Lee CW, Yun J, Oh SJ, Kang JS, Martinis SA, Hwang KY, Guo M, Han G, Han JM,, Kim S. Nat Commun, 8: 732, 2017
Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma.
Boulos S, Park MC, Zeibak M, Foo SY, Jeon YK, Kim YT, Motzik A, Tshori S, Hamburger T, Kim S, Nechushtan H, Razin E. Oncotarget, 8: 65186, 2017
Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane.
Choi H, Son JB, Kang J, Kwon J, Kim JH, Jung M, Kim SK, Kim S, Mun JY. Biochem Biophys Res Commun, 493: 1129, 2017
Purification and biophysical characterization of the AIMP2-DX2 protein.
Jha R, Cho HY, Mushtaq AU, Lee K, Kim DG, Kim S, Jeon YH. Protein Expr Purif, 132: 131, 2017
Mapping the contact surfaces in the Lamin A: AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry.
Tao Y, Fang P, Kim S, Guo M. Young NL, Marshall AG, PLos One, 12: e0181869, 2017
Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells.
Kim SB, Kim HR, Park MC, Cho S, Goughnour PC, Han D, Yoon I, Kim Y, Kang T, Song E, Kim P, Choi H, Mun JY, Song C, Lee S, Jung HS, Kim S. J Cell Biol, 216: 2201, 2017
Separation of extracellular nanovesicles and apoptotic bodies from cancer cell culture broth using tunable microfluidic systems.
Shin S, Han D, Park MC, Mun JY, Choi J, Chun H, Kim S, Hong JW. Sci rep, 7: 9907, 2017
Data on optimization of expression and purification of AIMP2-DX2 protein in Escherichia coli.
Jha R, Cho HY, Mushtaq AU, Lee K, Kim DG, Kim S, Jeon YH. Data Brief, 11: 533, 2017
Ratio of autoantibodies of tumor suppressor AIMP2 and Its oncogenic variant is associated with clinical outcome in lung cancer.
Jung JY, Kim EY, Kim A, Chang J, Kwon NH, Moon Y, Kang EJ, Sung JS, Shim H, Kim S, Chang YS. J Cancer, 8: 1347, 2017
Fragment-based methods for the discovery of inhibitors modulating lysyl-tRNA synthetase and laminin receptor interaction.
Cho HY, Kim S, Jeon YH. Methods, 113: 56, 2017
2016
Discovery of leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Yoon S, Kim JH, Koh Y, Tran PT, Ann J, Yoon I, Jang J, Kim WK, Lee S, Lee J, Kim S, Lee J. J Med Chem, 59: 10322, 2016
Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis.
Young HJ, Lee JW, Kim S. Biochim Biophys Acta, 1864: 1707, 2016
Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo.
Jeon H, Kim JH, Lee E, Jang YJ, Son JE, Kwon JY, Lim TG, Kim S, Park JH, Kim JE, Lee KW. Oncotarget. 7: 67223, 2016
Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection.
Ahn YH, Park S, Choi JJ, Park BK, Rhee KH, Kang E, Ahn S, Lee CH, Lee JS, Inn KS, Cho ML, Park SH, Park K, Park HJ, Lee JH, Park JW, Kwon NH, Shim H, Han BW, Kim P, Lee JY, Jeon Y, Huh JW, Jin M, Kim S. Nat Microbiol., 2: 16191, 2016
Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity.
Lee EY, Lee HC, Kim HK, Jang SY, Park SJ, Kim YH, Kim JH, Hwang J, Kim JH, Kim TH, Arif A, Kim SY, Choi YK, Lee C, Lee CH, Jung JU, Fox PL, Kim S, Lee JS, Kim MH. Nat Immunol, 17: 1252, 2016
Leucyl-tRNA synthetase activates Vps34 in amino acid-sensing mTORC1 signaling.
Yoon MS, Son K, Arauz E, Han JM, Kim S, Chen J. Cell Rep, 16: 1510, 2016
Identification of a new morpholine scaffold as a P2Y12 receptor antagonist.
Ahn YH, Lee JY, Park HD, Kim TH, Park MC, Choi G, Kim S. Molecules, 21: 1114, 2016
Integrative analysis of mutational and transcriptional profiles reveals driver mutations of metastatic breast cancers.
Lee JH, Zhao XM, Yoon I, Lee JY, Kwon NH, Wang YY, Lee KM, Lee MJ, Kim J, Moon HG, In Y, Hao JK, Park KM, Noh DY, Han W, Kim S. Cell Discov, 2: 16025, 2016
Oncogenic mutation of AIMP2/p38 inhibits its tumor suppressive interaction with smurf2.
Kim DG, Lee JY, Lee JH, Cho HY, Kang BS, Jang SY, Kim MH, Guo M, Han JM, Kim SJ, Kim S. Cancer Res, 76: 3422, 2016
AIMP2 controls intestinal stem cell compartments and tumorigenesis by modulating Wnt/β-catenin signaling.
Yum MK, Kang JS, Lee AE, Jo YW, Seo JY, Kim HA, Kim YY, Seong J, Lee EB, Kim JH, Han JM, Kim S, Kong YY. Cancer Res, 76: 4559, 2016
O-GlcNAcylation of orphan nuclear receptor ERRγ promotes hepatic gluconeogenesis.
Misra J, Kim DK, Jung YS, Kim HB, Kim YH, Yoo EK, Kim BG, Kim S, Lee IK, Harris RA, Kim JS, Lee CH, Cho JW, Choi HS. Diabetes, 65: 2835, 2016
Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor.
Yoon S, Kim JH, Yoon I, Kim C, Kim SE, Koh Y, Jeong SJ, Lee J, Kim S, Lee J. Bioorg Med Chem Lett, 26: 3038, 2016
Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cell‑extracellular matrix adhesion for migration.
Nam SH, Kang M, Ryu J, Kim HJ, Kim D, Kim DG, Kwon NH, Kim S, Lee JW. Int J Oncol, 48: 1553, 2016
Novel morphological and genetic analysis of cancer cells in a 3D microenvironment identifies STAT3 as a regulator of tumor permeability barrier function.
Park MC, Jeong H, Son SH, Kim Y, Han D, Goughnour PC, Kang T, Kwon NH, Moon HE, Paek SH, Hwang D, Seol HJ, Nam DH, Kim S. Cancer Res, 76: 1044, 2016
2015
PharmDB-K: integrated bio-pharmacological network database for 1 Traditional Korean Medicine.
Lee JH, Park KM, Han DJ, Bang NY, Kim DH, Na H, Lim S, Kim TB, Kim DG, Kim HJ, Chung Y, Sung SH, Surh YJ, Kim S. Han BW, Plos One, 10: e0142624, 2015
Assembly of multi-tRNA synthetase complex via heterotetrameric glutathione transferase-homology domains.
Cho HY, Maeng SJ, Cho HJ, Choi YS, Chung JM, Lee S, Kim HK, Kim JH, Eom CY, Kim YG, Guo M, Jung H, Kang BS, Kim S. J Biol Chem, 290: 29313, 2015
Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer.
Park H, Cho SY, Kim H, Na D, Han JY, Chae J, Park C, Park OK, Min S, Kang J, Choi B, Min J, Kwon JY, Suh YS, Kong SH, Lee HJ, Liu ET, Kim JI, Kim S, Yang HK, Lee C. Proc Natl Acad Sci U S A, 112: 12492, 2015
Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.
Nam SH, Kim D, Lee MS, Lee D, Kwak TK, Kang M, Ryu J, Kim HJ, Song HE, Choi J, Lee GH, Kim SY, Park SH, Kim DG, Kwon NH, Kim TY, Thiery JP, Kim S, Lee JW. Oncotarget, 6: 21655, 2015
Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Fang P, Yu X, Jeong SJ, Mirado A, Chen K, Chen X, Kim S, Francklyn CS and Guo M. Nat Commmun, 6: 6402, 2015
Screening of quinoline, 1, 2-benzoxazine, and 1, 3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis.
Bharathkumar H, Mohan CD, Rangappa S, Kang T, Keerthy HK, Fuchs JE, Kwon NH, Bender A, Kim S, Basappa and Rangappa KS. Org Biomol Chem, 13 : 9381, 2015
AIMP1 negatively regulates PPARg: Implication in adipogenesis.
Kim JH, Han JM, and Kim S. Receptors Clin Investig, 2: e377, 2015
Tpl2 induces castration resistant prostate cancer progression and metastasis.
Lee HW, Cho HJ, Lee SJ, Song HJ, Cho HJ, Park MC, Seol HJ, Lee JI, Kim S, Lee HM, Choi HY, Nam DH, Joo KM. Int J Cancer, 136: 2065, 2015
Multi-enzyme aminoacyl tRNA synthetase complex component AIMp1/p43 as an important Th1 mediator (IRC7P.428).
Liang D, Halpert M, Konduri V, Chen Y, Kim DY, Kim S, Levitt J, Decker W. J Immunol, 194: 128, 2015
A novel in vitro permeability assay using three-dimensional cell culture system.
Lee JB, Son SH, Park MC, Kim TH, Kim MG, Yoo SD, Kim S. J Biotechnol, 205: 93, 2015
The BioMart community portal: an innovative alternative to large, centralized data repositories.
Smedley D, Haider S, Durinck S, Pandini L, Provero P, Allen J, Arnaiz O, Awedh MH, Baldock R, Barbiera G, Bardou P, Beck T, Blake A, Bonierbale M, Brookes AJ, Bucci G, Buetti I, Burge S, Cabau C, Carlson JW, Chelala C, Chrysostomou C, Cittaro D, Collin O, Cordova R, Cutts RJ, Dassi E, Di Genova A, Djari A,Esposito A, Estrella H, Eyras E, Fernandez-Banet J, Forbes S, Free RC, Fujisawa T, Gadaleta E, Garcia-Manteiga JM, Goodstein D, Gray K, Guerra-Assunção JA, Haggarty B, Han DJ, Han BW, Harris T, Harshbarger J, Hastings RK, Hayes RD, Hoede C, Hu S, Hu ZL, Hutchins L, Kan Z, Kawaji H, Keliet A, Kerhornou A, Kim S, Kinsella R, Klopp C, Kong L, Lawson D, Lazarevic D, Lee JH, Letellier T, Li CY, Lio P, Liu CJ, Luo J, Maass A, Mariette J, Maurel T, Merella S, Mohamed AM, Moreews F, Nabihoudine I, Ndegwa N, Noirot C, Perez-Llamas C, Primig M, Quattrone A, Quesneville H, Rambaldi D, Reecy J, Riba M, Rosanoff S, Saddiq AA, Salas E, Sallou O, Shepherd R, Simon R, Sperling L, Spooner W, Staines DM, Steinbach D, Stone K, Stupka E, Teague JW, Dayem Ullah AZ, Wang J, Ware D, Wong-Erasmus M, Youens-Clark K, Zadissa A, Zhang SJ, Kasprzyk A. Nucleic Acids Res, 43: W589, 2015
Comprehensive data resources and analytical tools for pathological association of aminoacyl tRNA synthetases with cancer.
Lee JH, You S, Hyeon DY, Kang B, Kim H, Park KM, Han B, Hwang D, Kim S. Database, 2015: bav022, 2015
1H, 13C and 15N resonance assignment of WHEP domains of human glutamyl-prolyl tRNA synthetase.
Shin C, Hwang GS, Ahn HC, Kim S, Kim KS. Biomol NMR Assign, 9: 25, 2015
2014
miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18.
Lee S, Yu KR, Ryu YS, Oh YS, Hong IS, Kim HS, Lee JY, Kim S, Seo KW, Kang KS. Age, 36: 9724, 2014
A general strategy for generating intact, full-length IgG antibodies that penetrate into the cytosol of living cells.
Choi DK, Bae J, Shin SM, Shin JY, Kim S, Kim YS. MAbs, 6: 1402, 2014
Structure of the ArgRS–GlnRS–AIMP1 complex and its implications for mammalian translation.
Fu Y, Kim Y, Jin KS, Kim HS, Kim JH, Wang D, Park M, Jo CH, Kwon NH, Kim D, Kim MH, Jeon YH, Hwang KY, Kim S, Cho Y. Proc Natl Acad Sci U S A, 111: 15084, 2014
Characterization of the interaction between lysyl-tRNA synthetase and laminin receptor by NMR.
Cho HY, Ul Mushtaq A, Lee JY, Kim DG, Seok MS, Jang M, Han BW, Kim S, Jeon YH. FEBS Lett, 588: 2851, 2014
AIMP1/p43 negatively regulates adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma.
Kim JH, Lee JH, Park MC, Yoon I, Kim K, Lee M, Choi HS, Han JM, Kim S. J Cell Sci, 127: 4483, 2014
Promiscuous methionyl-tRNA synthetase mediates adaptive mistranslation against oxidative stresses.
Lee JY, Kim DG, Kim BG, Yang WS, Hong J, Kang T, Oh YS, Kim KR, Han BW, Hwang BJ, Kang BS, Kang MS, Kim MH, Kwon NH, Kim S. J Cell Sci, 127: 4234, 2014
Adenoviral-mediated mouse model of motor impairment in distal spinal muscular atrophy type V.
Seo AJ, Park BS, Jeong NY, Kim DY, Kim S, Park C, Jung JY, Huh YB. Anim Cells Syst, 18: 311, 2014
Extracellular activities of aminoacyl-tRNA synthetases: new mediators for cell-cell communication.
Son SH, Park MC, Kim S. Top Curr Chem, 344: 145, 2014
Association of aminoacyl-tRNA synthetases with cancer.
Kim D, Kwon NH, Kim S. Top Curr Chem, 344: 207, 2014
Translational validation of personalized treatment strategy based on genetic characteristics of glioblastoma.
Oh YT, Cho HJ, Kim J, Lee JH, Rho K, Seo YJ, Choi YS, Jung HJ, Song HS, Kong DS, Seol HJ, Lee JI, Yoon Y, Kim S, Nam DH, Joo KM. PLoS One, 9: e103327, 2014
Degradation of AIMP1/p43 Induced by hepatitis C virus E2 leads to upregulation of TGF-β signaling and increase in surface expression of gp96.
Kim MS, Kim S, Myung H. PLoS One, 9: e96302, 2014
Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction.
Kim DG, Lee JY, Kwon NH, Pengfei Fang, Qian Zhang, Jing Wang, Nicolas L. Young, Alan G. Marshall, Min Guo, Cho HY, AmeeqUl Mushtaq, Jeon YH, Choi JW, Han JM, Kang HW, Joo JE, Hur Y, Kang W, Yang H, Nam DH, Lee MS, Lee JW, Kim ES, Moon A, Kim K, Kim D, Kang EJ, Moon Y, Rhee KH, Han BW, Yang JS, Han YH, Yang WS, Lee C, Ming-Wei Wang, Kim S. Nat Chem Biol, 10: 29, 2014
Protein-protein interactions and multi-component complexes of aminoacyl-tRNA synthetases.
Kim JH, Han JM, Kim S. Top Curr Chem, 344: 119, 2014
A novel adenoviral vector-mediated mouse model of Charcot-Marie-Tooth type 2D (CMT2D).
Seo AJ, Shin YH, Lee SJ, Kim D, Park BS, Kim S, Choi KH, Jeong NY, Park C, Jang JY, Huh Y, Jung J. J Mol Histol, 45: 121, 2014
2013
Tumor Progression Locus 2 (Tpl2) kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma.
Lee HW, Joo KM, Lim JE, Cho HJ, Cho HJ, Park MC, Seol HJ, Seo SI, Lee JI, Kim S, Jeong BC, Nam DH. Mol Cancer Res, 11: 1375, 2013
Identification of upstream regulators for prognostic expression signature genes in colorectal cancer.
Bae T, Rho K, Choi JW, Horimoto K, Kim W, Kim S. BMC Syst Biol, 7: 86, 2013
Identification of master regulator candidates in conjunction with network screening and inference.
Saito S, Zhou X, Bae T, Kim S, Horimoto K. Int J Data Min Bioinform, 8: 366, 2013
Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.
Son J, Lee EH, Park M, Kim JH, Kim J, Kim S, Jeon JH, Hwang KY. Acta Crystallogr D Biol Crystallogr, 69: 2136, 2013
Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumour regression.
Lee HS, Kim DG, Oh YS, Kwon NH, Lee JY, Kim D, Park SH, Song JH, Lee S, Han JM, Park BJ, Lee J, Kim S. Biochem J, 454: 411, 2013
Multiple reaction monitoring of multiple low-abundance transcription factors in whole lung cancer cell lysates.
Kim JS, Lee Y, Lee MY, Shin J, Han JM, Yang EG, Yu MH, Kim S, Hwang D, Lee C. J Proteome Res, 12: 2582, 2013
Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex.
Kim KR, Park SH, Kim HS, Rhee KH, Kim BG, Kim DG, Park MS, Kim HJ, Kim S, Han BW. Proteins, 81: 1840, 2013
Patient-specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ.
Joo KM, Kim J, Jin J, Kim M, Seol HJ, Muradov J, Yang H, Choi YL, Park WY, Kong DS, Lee JI, Ko YH, Woo HG, Lee J, Kim S, Nam DH. Cell Rep, 3: 260, 2013
Structural switch of lysyl-tRNA synthetase between translation and transcription.
Ofir-Birin Y, Fang P, Bennett SP, Zhang HM, Wang J, Rachmin I, Shapiro R, Song J, Dagan A, Pozo J, Kim S, Marshall AG, Schimmel P, Yang XL, Nechushtan H, Razin E, Guo M. Mol Cell, 49: 30, 2013
2012
Identification of CD23 as a functional receptor for the proinflammatory cytokine AIMP1/p43.
Kwon HS, Park MC, Kim DG, Cho K, Park YW, Han JM, Kim S. J Cell Sci, 125: 4620, 2012
AIMP3/p18 controls translational initiation by mediating the delivery of charged initiator tRNA to initiation complex.
Kang T, Kwon NH, Lee JY, Park MC, Kang E, Kim HH, Kang TJ, Kim S. J Mol Biol, 423: 475, 2012
Cancer association study of aminoacyl-tRNA synthetase signaling network in glioblastoma.
Kim YW, Kwon C, Liu JL, Kim SH, Kim S. PLoS One, 7: e40960, 2012
CDA: Combinatorial drug discovery using transcriptional response modules.
Lee J-H, Kim DG, Bae TJ, Rho K, Ki J-T, Lee J-J, Jang YJ, Kim BC, Park KM, Kim S. PLoS One, 7: e42573, 2012
Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug.
Lee HS, Bae T, Lee JH, Kim DG, Oh YS, Jang Y, Kim JT, Lee JJ, Innocenti A, Supuran CT, Chen L, Rho K, Kim S. BMC Syst Biol, 6: 80, 2012
Interaction of two translational components, lysyl-tRNA synthetase and p40/37LRP, in plasma membrane promotes laminin-dependent cell migration.
Kim DG, Choi JW, Lee JY, Kim H, Oh YS, Lee JW, Tak YK, Song JM, Razin E, Yun S-H, Kim S. FASEB J, 26: 4142, 2012
AIMP1 deficiency enhances airway hyperreactivity in mice via increased T(H)2 immune responses.
Hong HJ, Kim E, Jung MY, Kim S, Kim TS. Clin Immunol, 143: 256, 2012
Lentiviral vector-mediated shRNA against AIMP2-DX2 suppresses lung cancer cell growth through blocking glucose uptake.
Chang SH, Chung YS, Hwang SK, Kwon JT, Minai-Tehrani A, Kim S, Park SB, Kim YS, Cho MH. Mol Cells, 33: 553, 2012
Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer.
Choi JW, Lee JW, Kim JK, Jeon HK, Choi JJ, Kim DG, Kim BG, Nam DH, Kim HJ, Yun SH, Kim S. J Mol Cell Biol, 4: 164, 2012
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.
Sajish M, Zhou Q, Kishi S, Valdez DM Jr, Kapoor M, Guo M, Lee S, Kim S, Yang XL, Schimmel P. Nat Chem Biol, 8: 547, 2012
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.
Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH, Kim S. Cell, 149: 410, 2012
Chemical modulators working at pharmacological interface of target proteins.
Jeon YH, Lee JY, Kim S. Bioorg Med Chem, 20: 1893, 2012
Selecting SNPs for pharmacogenomic association study.
Ahn TJ, Park K, Son DS, Huh N, Oh S, Bae T, Park JS, Lee JH, Rho K, Kim S, Park T, Lee K. Int J Data Min Bioinform, 6: 521, 2012
Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis.
Park MC, Kang T, Jin D, Han JM, Kim SB, Park YJ, Cho K, Park YW, Guo M, He W, Yang XL, Schimmel P, Kim S. Proc Natl Acad Sci U S A, 109: E640, 2012
2011
Enhancement of toll-like receptor 2-mediated immune responses by AIMP1, a novel cytokine, in mouse dendritic cells.
Kim E, Hong HJ, Cho D, Han JM, Kim S, Kim TS. Immunology, 134: 73, 2011
Entamoeba lysyl-tRNA synthetase contains a cytokine-like domain with chemokine activity towards human endothelial cells.
Castro de Moura M, Miro F, Han JM, Kim S, Celada A, Ribas de Pouplana L. PLoS Negl Trop Dis, 5: e1398, 2011
Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3.
Kwon NH, Kang T, Lee JY, Kim HH, Kim HR, Hong J, Oh YS, Han JM, Ku MJ, Lee SY, Kim S. Proc Natl Acad Sci U S A, 108: 19635, 2011
Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping.
Kim S, You S, Hwang D. Nat Rev Cancer, 11: 708, 2011
Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis.
Choi JW, Kim DG, Lee AE, Kim HR, Lee JY, Kwon NH, Shin YK, Hwang SK, Chang SH, Cho MH, Choi YL, Kim J, Oh SH, Kim B, Kim SY, Jeon HS, Park JY, Kang HP, Park BJ, Han JM, Kim S. PLoS Genet, 7: e1001351, 2011
Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells.
Carmi-Levy I, Motzik A, Ofir-Birin Y, Yagil Z, Yang CM, Kemeny DM, Han JM, Kim S, Kay G, Nechushtan H, Suzuki R, Rivera J, Razin E. Mol Cell Biol, 31: 2111, 2011
GARNET – gene set analysis with exploration of annotation relations.
Rho K, Kim B, Jang Y, Lee S, Bae T, Seo J, Seo C, Lee J, Kang H, Yu U, Kim S, Lee S, Kim WK. BMC Bioinformatics, 12: S25, 2011
2010
Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice.
Oh YS, Kim DG, Kim G, Choi EC, Kennedy BK, Suh Y, Park BJ, Kim S. Aging Cell, 9: 810, 2010
Toll-like receptor 4-mediated c-Jun N-terminal kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation.
Kim G, Han JM, Kim S. Biochem Biophys Res Commun, 397: 100, 2010
Autoantibodies against aminoacyl-tRNA synthetase: novel diagnostic marker for type 1 diabetes mellitus.
Park SG, Park HS, Jeong IK, Cho YM, Lee HK, Kang YS, Kim S, Park KS. Biomarkers, 15: 358, 2010
Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs): a triad for cellular homeostasis.
Park SG, Choi EC, Kim S. IUBMB Life, 62: 296, 2010
Identification of gp96 as a novel target for treatment of autoimmune disease in mice.
Han JM, Kwon NH, Lee JY, Jeong SJ, Jung HJ, Kim HR, Li Z, Kim S. PLoS One, 5: e9792, 2010
Antitumor activity and pharmacokinetic properties of ARS-interacting multi-functional protein 1 (AIMP1/p43).
Han JM, Myung H, Kim S. Cancer Lett, 287: 157, 2010
Molecular docking study of aminoacyl-tRNA synthetases with ligand molecules from four different scaffolds.
Bharatham N, Bharatham K, Lee Y, Kim SM, Lazar P, Baek AY, Park CN, Eum HS, Ha HJ, Yun SY, Lee WK, Kim S, Lee KW. Bull. Korean Chem. Soc, 31: 606, 2010
2009
A theoretical model for p53 dynamics: identifying optimal therapeutic strategy for its activation and stabilization.
Kim DH, Rho K, Kim S. Cell Cycle, 8: 3707, 2009
MSC p43 required for axonal development in motor neurons. Zhu X, Liu Y, Yin Y, Shao A, Zhang B, Kim S, Zhou J.
Proc Natl Acad Sci U S A, 106: 15944, 2009
Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis.
Choi JW, Um JY, Kundu JK, Surh YJ, Kim S, Carcinogenesis, 30: 1638, 2009
LysRS serves as a key signaling molecule in the immune response by regulating gene expression.
Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E. Mol Cell, 34: 603, 2009
The physiological role of lysyl tRNA synthetase in the immune system.
Nechushtan H, Kim S, Kay G, Razin E. Adv Immunol, 103: 1, 2009
AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2.
Choi JW, Kim DG, Park MC, Um JY, Han JM, Park SG, Choi EC, Kim S. J Cell Sci, 122: 2710, 2009
2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors.
Farhanullah, Kang T, Yoon EJ, Choi EC, Kim S, Lee J. Eur J Med Chem, 44: 239, 2009
2008
AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53.
Han JM, Park BJ, Park SG, Oh YS, Choi SJ, Lee SW, Hwang SK, Chang SH, Cho MH, Kim S. Proc Natl Acad Sci U S A, 105: 11206, 2008
Aminoacyl tRNA synthetases and their connections to disease.
Park SG, Schimmel P, Kim S. Proc Natl Acad Sci U S A, 105: 11043, 2008
Aminoacyl-tRNA synthetase-interacting multi-functional protein 1/p43: an emerging therapeutic protein working at systems level.
Lee SW, Kim G, Kim S, Expert Opin Drug Discov, 3: 945, 2008
AIMP1/p43 downregulates TGF-beta signaling via stabilization of smurf2.
Lee YS, Han JM, Son SH, Choi JW, Jeon EJ, Bae SC, Park YI, Kim S. Biochem Biophys Res Commun, 371: 395, 2008
Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM.
Kim KJ, Park MC, Choi SJ, Oh YS, Choi EC, Cho HJ, Kim MH, Kim SH, Kim DW, Kim S, Kang BS. J Biol Chem, 283: 14032, 2008
AIMP1/p43 protein induces the maturation of bone marrow-derived dendritic cells with T helper type 1-polarizing ability.
Kim E, Kim SH, Kim S, Cho D, Kim TS. J Immunol, 180: 2894, 2008
2007
Discovery of novel indazole-linked triazoles as antifungal agents.
Park JS, Yu KA, Kang TH, Kim S, Suh YG. Bioorg Med Chem Lett, 17: 3486, 2007
Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases.
Han JM, Park SG, Liu B, Park BJ, Kim JY, Jin CH, Song YW, Li Z, Kim S. Am J Pathol, 170: 2042, 2007
2006
Multi-functional proteins in tumorigenesis: aminoacyl-tRNA synthetases and translational components.
Lee SW, Kang YS, Kim S. Curr. Proteomics, 3: 233, 2006
Hierarchical network between the components of the multi-tRNA synthetase complex: implications for complex formation.
Han JM, Lee MJ, Park SG, Lee SH, Razin E, Choi EC, Kim S. J Biol Chem, 281: 38663, 2006
Hormonal activity of AIMP1/p43 for glucose homeostasis.
Park SG, Kang YS, Kim JY, Lee CS, Ko YG, Lee WJ, Lee KU, Yeom YI, Kim S. Proc Natl Acad Sci U S A, 103: 14913, 2006
Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors.
Farhanullah, Kim SY, Yoon EJ, Choi EC, Kim S, Kang T, Samrin F, Puri S, Lee J. Bioorg Med Chem, 14: 7154, 2006
Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors.
Kim SY, Lee YS, Kang T, Kim S, Lee J. Bioorg Med Chem Lett, 16: 4898, 2006
AIMP3 haploinsufficiency disrupts oncogene-induced p53 activation and genomic stability.
Park BJ, Oh YS, Park SY, Choi SJ, Rudolph C, Schlegelberger B, Kim S. Cancer Res, 66: 6913, 2006
Antitumor activity of the novel human cytokine AIMP1 in an in vivo tumor model.
Lee YS, Han JM, Kang T, Park YI, Kim HM, Kim S. Mol Cells, 21: 213, 2006
Do aminoacyl-tRNA synthetases have biological functions other than in protein biosynthesis.
Park SG, Kim S. IUBMB Life, 58: 556, 2006
Structural separation of different extracellular activities in aminoacyl-tRNA synthetase-interacting multi-functional protein, p43/AIMP1.
Han JM, Park SG, Lee Y, Kim S. Biochem Biophys Res Commun, 342: 113, 2006
The novel cytokine p43 induces IL-12 production in macrophages via NF-kappaB activation, leading to enhanced IFN-gamma production in CD4+ T cells.
Kim E, Kim SH, Kim S, Kim TS. J Immunol, 176: 256, 2006
2005
Aminoacyl-tRNA synthetase-interacting multi-functional protein, p43, is imported to endothelial cells via lipid rafts.
Yi JS, Lee JY, Chi SG, Kim JH, Park SG, Kim S, Ko YG. J Cell Biochem, 96: 1286, 2005
Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.
Ko HS, von Coelln R, Sriram SR, Kim SW, Chung KK, Pletnikova O, Troncoso J, Johnson B, Saffary R, Goh EL, Song H, Park BJ, Kim MJ, Kim S, Dawson VL, Dawson TM. J Neurosci, 25: 7968, 2005
Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers.
Park SG, Ewalt KL, Kim S. Trends Biochem Sci, 30: 569, 2005
Inactivation of organellar glutamyl- and seryl-tRNA synthetases leads to developmental arrest of chloroplasts and mitochondria in higher plants.
Kim YK, Lee JY, Cho HS, Lee SS, Ha HJ, Kim S, Choi D, Pai HS. J Biol Chem, 280: 37098, 2005
Deoxyribosyl analogues of methionyl and isoleucyl sulfamate adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
Kim SE, Kim SY, Kim S, Kang T, Lee J. Bioorg Med Chem Lett, 15: 3389, 2005
Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response.
Park SG, Kim HJ, Min YH, Choi EC, Shin YK, Park BJ, Lee SW, Kim S. Proc Natl Acad Sci U S A, 102: 6356, 2005
The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR.
Park BJ, Kang JW, Lee SW, Choi SJ, Shin YK, Ahn YH, Choi YH, Choi D, Lee KS, Kim S. Cell, 120: 209, 2005
The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair.
Park SG, Shin H, Shin YK, Lee Y, Choi EC, Park BJ, Kim S. Am J Pathol, 166: 387, 2005
2004
Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation.
Sampath P, Mazumder B, Seshadri V, Gerber CA, Chavatte L, Kinter M, Ting SM, Dignam JD, Kim S, Driscoll DM, Fox PL. Cell, 119: 195, 2004
Aminoacyl-tRNA synthetase complexes: beyond translation.
Lee SW, Cho BH, Park SG, Kim S. J Cell Sci, 117: 3725, 2004
Effect of solvent on the surface of protein chip plate.
Hyun JW, Yun MY, An SM, Noh SJ, Huh YD, Park H, Song YS, Pyee JK, Kim R, Kim S. J Kor Inst Surf Eng, 37: 1, 2004
Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assembly.
Halwani R, Cen S, Javanbakht H, Saadatmand J, Kim S, Shiba K, Kleiman L. J Virol, 78: 7553, 2004
Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents.
Jang SY, Ha YH, Ko SW, Lee W, Lee J, Kim S, Kim YW, Lee WK, Ha HJ. Bioorg Med Chem Lett, 14: 3881, 2004
Nuclear localization of aminoacyl-tRNA synthetases using single-cell capillary electrophoresis laser-induced fluorescence analysis.
Gunasekera N, Lee SW, Kim S, Musier-Forsyth K, Arriaga E. Anal Chem, 76: 4741, 2004
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase.
Kise Y, Lee SW, Park SG, Fukai S, Sengoku T, Ishii R, Yokoyama S, Kim S, Nureki O. Nat Struct Mol Biol, 11: 149, 2004
2003
Structure of the N-terminal extension of human aspartyl-tRNA synthetase: implications for its biological function.
Cheong HK, Park JY, Kim EH, Lee C, Kim S, Kim Y, Choi BS, Cheong C. Int J Biochem Cell Biol, 35: 1548, 2003
Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation.
Kim MJ, Park BJ, Kang YS, Kim HJ, Park JH, Kang JW, Lee SW, Han JM, Lee HW, Kim S. Nat Genet, 34: 330, 2003
In vitro development of resistance to a novel fluoroquinolone, DW286, in methicillin-resistant Staphylococcus aureus clinical isolates.
Kim MJ, Yun HJ, Kang JW, Kim S, Kwak JH, Choi EC. J Antimicrob Chemother, 51: 1011, 2003
Solution structure and p43 binding of the p38 leucine zipper motif: coiled-coil interactions mediate the association between p38 and p43.
Ahn HC, Kim S, Lee BJ. FEBS Lett, 542: 119, 2003
Molecular network and functional implications of macromolecular tRNA synthetase complex.
Han JM, Kim JY, Kim S. Biochem Biophys Res Commun, 303: 985, 2003
A novel sol-gel method to produce the poly-L-lysine coated plate as a platform for protein chips.
Hyun JW, Kim SY, Lee S, Park H, Pyee JH, Kim S. Bull Korean Chem Soc, 24: 1, 2003
Prevalence and mechanisms of low- and high-level mupirocin resistance in staphylococci isolated from a Korean hospital.
Yun HJ, Lee SW, Yoon GM, Kim SY, Choi S, Lee YS, Choi EC, Kim S. J Antimicrob Chemother, 51: 619, 2003
Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics.
Kim S, Lee SW, Choi EC, Choi SY. Appl Microbiol Biotech, 61: 278, 2003
Protein immobilization on plasma-polymerized ethylenediamine-coated glass slides.
Kim J, Park H, Jung D, Kim S. Anal Biochem, 313: 41, 2003
2002
Signaling pathways for TNF production induced by human aminoacyl-tRNA synthetase-associating factor, p43.
Park H, Park SG, Kim J, Ko YG, Kim S. Cytokine, 20: 148, 2002
Protein adsorption on the nickel-coated glass slide for protein chips.
Hyun JW, Kim SY, Lee S, Park H, Pyee J, Kim S. Bull Korean Chem Soc, 23: 1, 2002
Retrovirus-specific packaging of aminoacyl-tRNA synthetases with cognate primer tRNAs.
Cen S, Javanbakht H, Kim S, Shiba K, Craven R, Rein A, Ewalt K, Schimmel P, Musier-Forsyth K, Kleiman L. J Virol, 76: 13111, 2002
Novel regulatory interactions and activities of mammalian tRNA synthetases.
Ko YG, Park H, Kim S. Proteomics, 2: 1304, 2002
Dose-dependent biphasic activity of tRNA synthetase-associating factor, p43, in angiogenesis.
Park SG, Kang YS, Ahn YH, Lee SH, Kim KR, Kim KW, Koh GY, Ko YG, Kim S. J Biol Chem, 277: 45243, 2002
Agonist recognition sites in the cytosolic tails of vanilloid receptor 1.
Jung J, Lee SY, Hwang SW, Cho H, Shin J, Kang YS, Kim S, Oh U. J Biol Chem, 277: 44448, 2002
Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1.
Park HS, Cho SG, Kim CK, Hwang HS, Noh KT, Kim MS, Huh SH, Kim MJ, Ryoo K, Kim EK, Kang WJ, Lee JS, Seo JS, Ko YG, Kim S, Choi EJ. Mol Cell Biol, 22: 7721, 2002
p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance.
Kim JY, Kang YS, Lee JW, Kim HJ, Ahn YH, Park H, Ko YG, Kim S. Proc Natl Acad Sci U S A, 99: 7912, 2002
Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation.
Chang SY, Park SG, Kim S, Kang CY. J Biol Chem, 277: 8388, 2002
Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex.
Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S. Biochem Biphys Res Commun, 291: 158, 2002
Monocyte cell adhesion induced by a human aminoacyl-tRNA synthetase-associated factor, p43: identification of the related adhesion molecules and signal pathways.
Park H, Park SG, Lee JW, Kim T, Kim G, Ko YG, Kim S. J Leukoc Biol., 71: 223, 2002
2001
Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm.
Ko YG, Kang YS, Park H, Seol W, Kim J, Kim T, Park HS, Choi EJ, Kim S. J Biol Chem, 276: 39103, 2001
A cofactor of tRNA synthetase, p43, is secreted to up-regulate proinflammatory genes.
Ko YG, Park H, Kim T, Lee JW, Park SG, Seol W, Kim JE, Lee WH, Kim SH, Park JE, Kim S. J Biol Chem, 276: 23028, 2001
Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
Lee J, Kang SU, Kim SY, Kim SE, Kang MK, Jo YJ, Kim S. Bioorg Med Chem Lett, 11: 961, 2001
Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
Lee J, Kang SU, Kim SY, Kim SE, Job YJ, Kim S. Bioorg Med Chem Lett., 11: 965, 2001
Msx1 gene overexpression induces G1 phase cell arrest in human ovarian cancer cell line OVCAR3.
Park J, Park K, Kim S, Lee JH. Biochem Biophys Res Commun., 281: 1234, 2001
Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1.
Ko YG, Kim EY, Kim T, Park H, Park HS, Choi EJ, Kim S. J Biol Chem, 276: 6030, 2001
2000
A novel anti-tumor cytokine contains an RNA binding motif present in aminoacyl-tRNA synthetases.
Kim Y, Shin J, Li R, Cheong C, Kim K, Kim S. J Biol Chem, 275: 27062, 2000
Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis.
Ko YG, Kang YS, Kim EK, Park SG, Kim S. J Cell Biol, 149: 567, 2000
Death effector domain of a mammalian apoptosis mediator, FADD, induces bacterial cell death.
Lee SW, Ko YG, Bang S, Kim KS, Kim S. Mol Microbiol, 35: 1540, 2000
An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing.
Kim JE, Kim KH, Lee SW, Seol W, Shiba K, Kim S. Nucleic Acids Res, 28: 2866, 2000
Catalytic peptide of human glutaminyl-tRNA synthetase is essential for its assembly to the aminoacyl-tRNA synthetase complex.
Kim T, Park SG, Kim JE, Seol W, Ko YG, Kim S. J Biol Chem, 275: 21768, 2000
Structural analysis of multifunctional peptide motifs in human bifunctional tRNA synthetase: identification of RNA-binding residues and functional implications for tandem repeats.
Jeong EJ, Hwang GS, Kim KH, Kim MJ, Kim S, Kim KS. Biochemistry, 39: 15775, 2000
Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases.
Kang J, Kim T, Ko YG, Rho SB, Park SG, Kim MJ, Kwon HJ, Kim S. J Biol Chem, 275: 31682, 2000
1999
Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase.
Park SG, Jung KH, Lee JS, Jo YJ, Motegi H, Kim S, Shiba K. J Biol Chem, 274: 16673, 1999
Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex.
Rho SB, Kim MJ, Lee JS, Seol W, Motegi H, Kim S, Shiba K. Proc Natl Acad Sci U S A, 96 : 4488, 1999
Methionine analogue probes functionally important residues in active site of methionyl-tRNA synthetase.
Jo YJ, Lee SW, Jo MK, Lee JW, Kang MK, Yoon JH, Kim S. J Biochem Mol Biol, 32 : 547, 1999
Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase.
Lee J, Kang SU, Kang MK, Chun MW, Jo YJ, Kwak JH, Kim S. Bioorg Med Chem Lett, 9 : 1365, 1999
1998
Methionine analogues as inhibitors of methionyl-tRNA synthetase.
Lee J, Kang MK, Chun MW, Jo YJ, Kwak JH, Kim S. Bioorg Med Chem Lett, 8: 3511, 1998
Cloning and characterization of mitochondrial methionyl-tRNA synthetase from a pathogenic fungi Candida albicans.
Lee SW, Jo YJ, Kim S. Gene, 215 : 311, 1998
Biochemical and phylogenetic analyses of methionyl-tRNA synthetase isolated from a pathogenic microorganism, Mycobacterium tuberculosis.
Kim S, Jo YJ, Lee SH, Motegi H, Shiba K, Sassanfar M, Martinis SA. FEBS Lett, 427: 259, 1998
A multifunctional repeated motif is present in human bifunctional tRNA synthetase.
Rho SB, Lee JS, Jeong EJ, Kim KS, Kim YG, Kim S. J Biol Chem, 273: 11267, 1998
Abnormal protein enhances stress-induced cell death.
Kim SJ, Kim S. Biochem Biophy Res Comm, 243: 153, 1998
1997
Temperature sensitivity of a class I tRNA synthetase induced by artificial breakage of polypeptide chain.
Kim SJ, Kim S. Mol Cells, 7: 389, 1997
1996
Interaction between human tRNA synthetases involves repeated sequence elements Rho SB, Lee KH, Kim JW, Shiba K, Jo YJ, Kim S.
Proc Natl Acad Sci U S A, 93: 10128, 1996
Characterization of an Escherichia coli mutant, feeA, displaying resistance to the calmodulin inhibitor 48/80 and reduced expression of the rare tRNA3Leu.
Bouquin N, Chen MX, Kim S, Vannier F, Bernard S, Holland IB, Séror SJ. Mol Microbiol, 20: 853, 1996
A mechanism for reducing entropic cost of induced fit in protein-RNA recognition.
Ribas de Pouplana L, Auld DS, Kim S, Schimmel P. Biochemistry, 35: 8095, 1996
1995
Quantitative analysis of protein-RNA interaction in a class I tRNA synthetase by saturation mutagenesis.
Kim S. J Biochem Mol Biol, 28: 363, 1995
1994
An RNA binding site in a tRNA synthetase with a reduced set of amino acids.
Kim S, Ribas de Pouplana L, Schimmel P. Biochemistry, 33: 11040, 1994
1993
C-terminal peptide appendix in a class I tRNA synthetase needed for acceptor-helix contacts and microhelix aminoacylation.
Kim S, Landro JA, Gale AJ, Schimmel P. Biochemistry, 32: 13026, 1993
Diversified sequences of peptide epitope for same-RNA recognition.
Kim S, Ribas de Pouplana L, Schimmel P. Proc Natl Acad Sci U S A, 90 :10046, 1993
1992
Function independence of microhelix aminoacylation from anticodon binding in a class I tRNA synthetase.
Kim S, Schimmel P. J Biol Chem, 267: 15563, 1992
Lambda Int protein bridges between higher order complexes at two distant chromosomal loci attL and attR.
Kim S, Landy A. Science, 256: 198, 1992
1990
Mapping of a higher order protein-DNA complex: two kinds of long-range interactions in lambda attL.
Kim S, Moitoso de Vargas L, Nunes-Düby SE, Landy A. Cell, 63: 773, 1990
1989
DNA looping generated by DNA bending protein IHF and the two domains of lambda integrase.
Moitoso de Vargas L, Kim S, Landy A. Science, 244: 1457, 1989
Mutagenesis of slow-growing rhizobium japonicum with transposon Tn5.
Kim S, Rhee Y, Sun DK, Yoo IC. Kor J Microbiol, 26: 305, 1989
1987
Characterization and biovar. determination of agrobacterium tumefaciens T7 isolated in Korea.
Lee Y, Kim CH, Kim S, Yoo ID, Mheen TI. Kor J Microbiol, 25: 17, 1987
1986
Asymbiotic nitrogen fixation of R.japonicum in soybean nodule extract.
Kim S, Rhee Y, Kim CJ, Yoo ID, Mheen TI. Kor J Microbiol, 24: 127, 1986
Host specificities between soybean varieties and Rhizobium japonicum strains.
Kim CJ, Rhee Y, Kim S, Yoo ID, Mheen TI. J Kor Soc Soil, 19: 345, 1986
The inoculation effect of R.japonicum on the nodulation and nitrogen fixation activity in Glycine max with different kinds of soil.
Yoo ID, Kim CJ, Kim S, Rhee Y, Mheen TI. Kor J Appl Microbiol Bioeng, 14: 187, 1986
1985
Selection of R.japonicum strains for developing soybean inoculant and plasmid characterization.
Kim CJ, Kim S, Rhee y, Yoo ID, Mheen TI. J Kor Agr Chem Soc, 28: 149, 1985
Glycine effect on spheroplasting and nodule bacteroids of R.japonicum.
Kim S, Kim CJ, Rhee Y, Yoo ID, Mheen TI. Kor J Microbiology, 23: 197, 1985
Biochemical characterization of fast- and slow-growing R.japonicum.
Kim CJ, Kim S, Mheen TI. Kor J Microbiol Bioeng, 13: 13, 1985
The effect of nitrogen sources on the expression of nif gene in K. pneumoniae nif-lac gene fusants.
Kim S, Son HJ, Kim CJ, Mheen TI. Kor J Microbiol, 23: 20, 1985
1984
Instability kinetics of trp operon plasmid ColE1-trp in recombinant E.coli MV12 (pVH5) and MV12trpR(pVH5).
Kim S, Ryu DD. Biotechnol Bioeng, 26: 497, 1984
1982
Instability of trp operon recombinant plasmids in E.coli.
Kim S, Choi YC, Ryu DY, Lee SY. Kor Biochem J, 15: 305, 1982